319442-19-8

Basic information

• Product Name: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate
• Synonyms: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate
• CAS NO: 319442-19-8
• Molecular Formula: C9H8N2O3S
• Molecular Weight: 224.23642
• Mol File: 319442-19-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate(319442-19-8)
• EPA Substance Registry System: Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate(319442-19-8)

Safety Data

• Hazardous Substances Data: 319442-19-8(Hazardous Substances Data)

Usage

General Description

Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyrimidine-2-carboxylate is a chemical compound that belongs to the class of heterocyclic compounds. It is a derivative of thienopyrimidine, a bicyclic compound consisting of a thiene ring fused to a pyrimidine ring. Ethyl 4-oxo-3,4-dihydrothieno[3,2-d]pyriMidine-2-carboxylate is commonly used in the pharmaceutical industry for the synthesis of various drugs and pharmaceutical products. It possesses potential biological activities and pharmacological properties, making it a valuable building block for drug discovery and development. It is also utilized in the field of organic synthesis as a versatile intermediate in the preparation of various organic compounds.

Upstream product

• 95-92-1 oxalic acid diethyl ester 
• 147123-47-5 3-aminothiophene-2-carboxamide 
• 55341-87-2 3-aminothiophene-2-carboxylic acid 
• 22288-78-4 Methyl 3-aminothiophene-2-carboxylate 
• 623-49-4 ethyl cyanoformate 

Downstream Products

• 319442-18-7 ethyl 4-chlorothieno[3,2-d]pyrimidine-2-carboxylate 
• 1362709-96-3 1-(4-fluorophenyl)-1-(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)ethanol 
• 1362709-98-5 2-((4-fluorophenyl)(methoxy)methyl)-N-(5-methyl-1H-pyrazol-3-yl)thieno[3,2-d]pyrimidin-4-amine 
• 1362710-44-8 (4-chlorothieno[3,2-d]pyrimidin-2-yl)(4-fluorophenyl)methanone 
• 1362709-70-3 (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)methanone 
• 1362709-72-5 (4-fluorophenyl)(4-(5-methyl-1H-pyrazol-3-ylamino)thieno[3,2-d]pyrimidin-2-yl)methanol 

Relevant articles and documents

SUBSTITUTED 2- AMIDOQUINAZOL-4-ONES AS MATRIX METALLOPROTEINASE-13 INHIBITORS

The present invention provides a novel amide derivative having a matrix metalloproteinase inhibitory activity, and useful as a pharmaceutical agent, which is a compound represented by the formula (I) wherein ring A is an optionally substituted, nitrogen containing heterocycle, ring B is an optionally substituted monocyclic homocycle or an optionally substituted monocyclic heterocycle, Z is N or NR1 (R1 is a hydrogen atom or an optionally substituted hydrocarbon group), is a single bond or a double bond, R2 is a hydrogen atom or an optionally substituted hydrocarbon group, X is an optionally substituted spacer having 1 to 6 atoms, ring C is (1) an optionally substituted homocycle or (2) an optionally substituted heterocycle other than a ring represented by (II) (X′ is S, O, SO, or CH2), and at least one of ring B and ring C has substituent(s), provided that N-{(1S,2R)-1-(3,5-difluorobenzyl)-3-[(3-ethylbenzyl)amino]2 hydroxypropyl}5,6 dimethyl 4 oxo 1,4 dihydrothieno[2,3-d]pyrimidine-2-carboxamide is excluded, or a salt thereof.

THIENOPYRIDINE AND THIENOPYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF

Provided herein are thienopyridine and thienopyrimidine compounds of formula (I) for treatment of JAK kinase mediated diseases, including JAK2 kinase-, JAK3 kinase- or TYK2 kinase-mediated diseases. Also provided are pharmaceutical compositions comprising