319460-94-1

Basic information

• Product Name: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide
• Synonyms: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide;AG 13958;AG-013958;N-[2-Fluoro-5-({3-[(E)-2-(2-pyridinyl)vinyl]-1H-indazol-6-yl}amin o)phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-py;(E)-N-(2-Fluoro-5-((3-(2-(pyridin-2-yl)vinyl)-1H-indazol-6-yl)amino)phenyl)-1,3-dimethyl-1H-pyrazole-5-carboxamide
• CAS NO: 319460-94-1
• Molecular Formula: C₂₆H₂₂FN₇O
• Molecular Weight: 467
• Mol File: 319460-94-1.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 647.8±55.0 °C(Predicted)
• Appearance: /
• Density: 1.35±0.1 g/cm3(Predicted)
• PKA: 12.13±0.70(Predicted)
• CAS DataBase Reference: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide(319460-94-1)
• EPA Substance Registry System: N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide(319460-94-1)

Safety Data

• Hazardous Substances Data: 319460-94-1(Hazardous Substances Data)

Usage

General Description

N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide is a complex organic compound. Its structure consists of several substructures including a pyrazole, indazole and pyridine ring, all popular components in pharmaceuticals due to their versatile chemical properties. The compound also bears a fluoro group, known for increasing the strength and stability of organic compounds, and a carboxamide group, considered key pharmacophores in many drugs. N-[2-Fluoro-5-[[3-[(1E)-2-(2-pyridinyl)ethenyl]-1H-indazol-6-yl]amino]phenyl]-1,3-dimethyl-1H-pyrazole-5-carboxamide, as with many complex organics, may have potential pharmacological activities but no specific one is currently known. Hence, the precise biological function and potential applications in medicine or industry for this specific chemical require further investigation.

Relevant articles and documents

METHODS FOR PREPARING INDAZOLE COMPOUNDS

The invention relates to methods for preparing compounds of formula (I): or pharmaceutically acceptable salts or solvates thereof. Compounds of the formula (I) are useful as anti-angiogenesis agents and as agents for modulating and/or inhibiting the activity of protein kinases, thus providing treatments for cancer or other diseases associated with cellular proliferation mediated by protein kinases.