319472-91-8 Usage
Indazole Ring
A five-membered aromatic ring with three nitrogen atoms, providing the core structure of the compound and contributing to its potential biological activity.
6-Iodo Substituent
A single iodine atom attached to the indazole ring at the 6th position, which may influence the compound's reactivity, polarity, and lipophilicity.
3-[(1E)-2-Phenylethenyl] Group
A vinyl group (ethenyl) attached to a phenyl ring at the 2nd position, which is part of the compound's side chain and can be involved in various chemical reactions.
1-[[2-(Trimethylsilyl)ethoxy]methyl] Moiety
A trimethylsilyl (TMS) group attached to an ethoxymethyl group, which serves as a protecting group for alcohols in organic synthesis.
Trimethylsilyl (TMS) Group
A silicon-based protecting group consisting of three methyl groups, which can be used to temporarily block the reactivity of an alcohol group during chemical reactions.
Ethoxymethyl Group
A two-carbon chain with an ether (-O-) functional group, which connects the trimethylsilyl group to the main indazole ring structure.
Biological Activity
The presence of the indazole ring and phenylethenyl group suggests that 1H-Indazole,
6-iodo-3-[(1E)-2-phenylethenyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]- may have potential biological activity, as these motifs are found in certain pharmaceuticals and natural products.
Organic Synthesis Applications
The compound's trimethylsilyl group indicates its potential use as a protecting group in organic synthesis, allowing for selective reactions to occur on specific functional groups.
Medicinal Chemistry Potential
Due to its diverse reactivity and presence of biologically relevant functional groups, 1H-Indazole,
6-iodo-3-[(1E)-2-phenylethenyl]-1-[[2-(trimethylsilyl)ethoxy]methyl]- may have applications in medicinal chemistry for the development of new drugs or drug candidates.
Check Digit Verification of cas no
The CAS Registry Mumber 319472-91-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,1,9,4,7 and 2 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 319472-91:
(8*3)+(7*1)+(6*9)+(5*4)+(4*7)+(3*2)+(2*9)+(1*1)=158
158 % 10 = 8
So 319472-91-8 is a valid CAS Registry Number.
319472-91-8Relevant academic research and scientific papers
Indazole compounds and pharmaceutical compositions for inhibiting protein kinases, and methods for their use
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, (2008/06/13)
Indazole compounds that modulate and/or inhibit the activity of certain protein kinases are described. These compounds and pharmaceutical compositions containing them are capable of mediating tyrosine kinase signal transduction and thereby modulate and/or inhibit unwanted cell proliferation. The invention is also directed to the therapeutic or prophylactic use of pharmaceutical compositions containing such compounds, and to methods of treating cancer and other disease states associated with unwanted angiogenesis and/or cellular proliferation, such as diabetic retinopathy, neovascular glaucoma, rheumatoid arthritis, and psoriasis, by administering effective amounts of such compounds.
