31964-89-3

Usage

Derived from

Pyrimidine and phenol

Usage

Intermediate in the synthesis of pharmaceutical compounds

Potential applications

+ Precursor for the synthesis of heterocyclic compounds with biological activity
+ Antiviral and antitumor agent

Importance in the pharmaceutical industry

Promising candidate for further research and development

Chemical structure

Contributes to its properties and potential applications

Relevant academic research and scientific papers

Preparation method and application of N-(pyrimidine-2-yl) coumarin-7-amine derivative as protein kinase inhibitor

The invention discloses a cyclin-dependent kinase inhibitor. The cyclin-dependent kinase inhibitor comprises an N-(pyrimidine-2-yl) coumarin-7-amine derivative shown as a general formula (I). In-vitropharmacodynamic tests prove that the compound has a high-selectivity inhibition effect on CDK9 kinase, and can be applied to reducing or inhibiting the activity of CDK9 kinase in cells. The inventionalso discloses a preparation method of the inhibitor and application of the inhibitor in drugs for CDK family kinase mediated diseases, especially hyperproliferative diseases, virus-induced infectious diseases and cardiovascular diseases.