31968-33-9

Basic information

• Product Name: 2-ACETYL-3-AMINOTHIOPHENE
• Synonyms: 1-(5-Amino-2-thienyl)ethanone;BUTTPARK 85\18-13;2-ACETYL-3-AMINOTHIOPHENE;1-(3-AMINO-2-THIENYL)ETHAN-1-ONE;2-acetylthiophene-3-amine;1-(3-Aminothien-2-yl)ethan-1-one;1-(3-aMinothiophen-2-yl)ethan-1-one;1-(3-AMinothiophen-2-yl)ethanone
• CAS NO: 31968-33-9
• Molecular Formula: C₆H₇NOS
• Molecular Weight: 141.19
• Product Categories: Thiophenes
• Mol File: 31968-33-9.mol
• Article Data: 2

Chemical Properties

• Melting Point: 84-88°C
• Boiling Point: 120-125°C 0,8mm
• Flash Point: 120-125°C/0.8mm
• Appearance: /
• Density: 1.252 g/cm³
• Vapor Pressure: 0.000254mmHg at 25°C
• Refractive Index: 1.606
• Storage Temp.: 2-8°C
• Water Solubility: Insoluble in water.
• BRN: 1635973
• CAS DataBase Reference: 2-ACETYL-3-AMINOTHIOPHENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ACETYL-3-AMINOTHIOPHENE(31968-33-9)
• EPA Substance Registry System: 2-ACETYL-3-AMINOTHIOPHENE(31968-33-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 20/21/22-36-22
• Safety Statements: 22-36/37-26
• WGK Germany: 3
• PackingGroup: III
• Hazardous Substances Data: 31968-33-9(Hazardous Substances Data)

Usage

Uses

Dithienopyridines was synthesised from 2-Acetyl-3-aminothiophene. Also used as fine Intermediate.

InChI:InChI=1/C6H7NOS/c1-4(8)6-5(7)2-3-9-6/h2-3H,7H2,1H3

Upstream product

• 920-37-6 2-Chloroacrylonitrile 
• 24653-75-6 1-mercaptopropan-2-one 
• 57892-89-4 2-acetyl-3-azidothiophene 

Downstream Products

• 22390-25-6 Thieno<3,2-c>pyridazin 
• 1352450-73-7 (2-acetyl-thiophen-3-ylamino)-phenyl-acetic acid (R)-(1-aza-bicyclo[2.2.2]oct-3-yl) ester 
• 1352450-04-4 (3R)-3-(2-(2-acetylthiophen-3-ylamino)-2-phenylacetoxy)-1-(2-oxo-2-phenylethyl)-1-azoniabicyclo[2.2.2]octane trifluoroacetate 
• 1352450-72-6 2-(2-acetylthiophen-3-ylamino)-2-phenylacetic acid 
• 1189104-11-7 (2-Acetyl-thiophen-3-ylamino)-(4-methoxy-phenyl)-acetic acid 
• 69627-02-7 thieno[3,2-b]pyridin-7(4H)-one 
• 925668-99-1 2-(2-bromo-4,5-dimethoxyphenyl)-1-[3-N-(4-methylbenzenesulfonamido)-2-thienyl]ethanone 
• 925668-98-0 2-(2-bromo-4,5-dimethylphenyl)-1-[3-N-(4-methylbenzenesulfonamido)-2-thienyl]ethanone 
• 925668-97-9 2-(2-bromophenyl)-1-[3-N-(4-methylbenzenesulfonamido)-2-thienyl]ethanone 
• 925669-13-2 1-(3-amino-2-thienyl)-2-(2-bromo-4,5-dimethoxyphenyl)ethanone 
• 925669-12-1 1-(3-amino-2-thienyl)-2-(2-bromo-4,5-dimethylphenyl)ethanone 
• 925669-11-0 1-(3-amino-2-thienyl)-2-(2-bromophenyl)ethanone 
• 187334-32-3 N-[(2-acetyl-3-thienyl)]phthalimide 

Relevant articles and documents

Synthesis and chemistry of 4,5-dihydrothieno[3,2-b]pyrrol-6-ones - A heteroindoxyl

(Chemical Equation Presented) Flash vacuum pyrolysis (FVP) of 2-acetyl-3-azidothiophene gives 3-methylthieno[3,2-c]isoxazole as the major product at a furnace temperature of 350°C whereas at temperatures above 550°C the new heteroindoxyl 4,5-dihydrothieno[3,2-b]pyrrol-6-one is exclusively formed. The heteroindoxyl exists predominantly as the keto tautomer. It is O-protonated by TFA, N-acetylated by acetic anhydride, N-nitrosated by nitrous acid, and provides an N-methylene Meldrum's acid derivative on treatment with methoxymethylene Meldrum's acid. Reactions of 4,5-dihydrothieno[3,2-b] pyrrol-6-one with diazonium salts, with isatin, and with dimethyl acetylenedicarboxylate take place at the methylene position to provide a hydrazone, an indirubin analogue, and a succinate derivative, respectively. Oxidation of 4,5-dihydrothieno[3,2-b]pyrrol-6-one gives a heteroindigotin, which shows a hypsochromic shift in the UV spectrum, relative to indigotin itself.