3199-77-7

Basic information

• Product Name: 2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL
• Synonyms: 2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL;5-methoxy-2,3-dihydro-1H-inden-1-ol;5-methoxyindan-1-ol;5-METHOXY-1-INDANOL
• CAS NO: 3199-77-7
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 3199-77-7.mol

Chemical Properties

• Boiling Point: 307.8°C at 760 mmHg
• Flash Point: 144.1°C
• Appearance: /
• Density: 1.176g/cm³
• Vapor Pressure: 0.000308mmHg at 25°C
• Refractive Index: 1.584
• CAS DataBase Reference: 2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL(3199-77-7)
• EPA Substance Registry System: 2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL(3199-77-7)

Safety Data

• Hazardous Substances Data: 3199-77-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Dihydro-5-methoxy-1H-inden-1-ol is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs and medicinal compounds.
Used in Perfumery and Fragrance Industry:
2,3-DIHYDRO-5-METHOXY-1H-INDEN-1-OL is used as a fragrance ingredient in perfumes and fragrances due to its distinct aromatic odor, enhancing the sensory experience of these products.
Used in Research and Development:
2,3-Dihydro-5-methoxy-1H-inden-1-ol is used as a research compound for studying its potential medicinal properties, including antibacterial and antifungal activities, which can lead to the discovery of new treatments and therapies.
Used in Organic Compounds Synthesis:
It serves as a building block in the synthesis of various organic compounds, contributing to the advancement of organic chemistry and the creation of new materials and substances.

InChI:InChI=1/C10H12O2/c1-12-8-3-4-9-7(6-8)2-5-10(9)11/h3-4,6,10-11H,2,5H2,1H3

Upstream product

• 38005-82-2 2,3-dihydro-1H-indene-1,5-diol 
• 5111-69-3 5-methoxyindane 
• 1470-94-6 5-hydroxy-2,3-dihydro-1H-indene 
• 10516-71-9 3-(3-Methoxy-phenyl)-propionic acid 
• 79827-88-6 5-methoxyindan-1-yl 3,5-dinitrobenzoate 
• 5111-70-6 5-methoxy-1-indanone 

Downstream Products

• 79827-88-6 5-methoxyindan-1-yl 3,5-dinitrobenzoate 
• 469904-27-6 5-methoxyindene 1,2-oxide 
• 753020-50-7 5-methoxy-trans-1,2-indandiol 
• 753020-50-7 5-methoxy-cis-1,2-indandiol 
• 1359938-25-2 C₂₁H₂₃NO 
• 1359938-26-3 C₂₈H₂₉NO 
• 1359938-27-4 C₂₁H₂₅NO 
• 1359938-28-5 C₂₈H₃₁NO 
• 5111-69-3 5-methoxyindane 
• 52372-95-9 2,3-dihydro-5-methoxy-1H-inden-1-amine 

Relevant articles and documents

PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

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Br?nsted acid/visible-light-promoted Markovnikov hydroamination of vinylarenes with arylamines

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Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine

Efficient kinetic resolution of racemic 1-indanol derivatives was achieved using triphenylchlorosilane by asymmetric silylation in the presence of chiral guanidine catalysts. The chiral guanidine catalyst (R,R)-N-(1-(β-naphthyl)ethyl)benzoguanidine was found to be highly efficient as only 0.5 mol % catalyst loading was sufficient to catalyze the reaction of various substrates with appropriate conversion and high s-values (up to 89). This catalyst system was successfully applied to the gram-scale silylative kinetic resolution of racemic 1-indanol with high selectivity.

BICYCLICALLY SUBSTITUTED URACILS AND THE USE THEREOF

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SUBSTITUTED HETEROCYCLIC DERIVATIVES AS GPR AGONISTS AND USES THEREOF

The present invention generally relates to substituted heterocyclic derivatives (the compounds of Formula (I)), processes for their preparation, pharmaceutical compositions containing said compounds, their use as G-protein coupled receptor (GPR) agonists, particularly as GPR40 agonists and methods of using these compounds in the treatment of GPR40 mediated diseases or conditions such as Type 2 diabetes, obesity, dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.

AMINOINDANE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, AND THEIR USE IN THERAPY

The present invention relates to aminoindane derivatives of the formula (I) or a physiologically tolerated salt thereof. The invention relates to pharmaceutical compositions comprising such aminoindane derivatives, and the use of such aminoindane derivatives for therapeutic purposes. The aminoindane derivatives are GlyT1 inhibitors.

Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/- indanes and structurally modified derivatives: Potent and selective inhibitors of aldosterone synthase

Elevated aldosterone levels are key effectors for the development and progression of congestive heart failure and myocardial fibrosis. Recently, we proposed inhibition of aldosterone synthase (CYP11B2) as an innovative strategy for the treatment of these

Transition-state effects in acid-catalyzed aryl epoxide hydrolyses

The hydronium ion-catalyzed hydrolyses of 5-methoxyindene 1,2-oxide and of 6-methoxy-1,2,3,4-tetrohydronaphthalene-1,2-epoxide were each found to yield 75-80% of cis diol and only 20-25% of trans diol as hydrolysis products. The relative stabilities of the cis and trans diols in each system were determined by treating either cis or trans diols with perchloric acid in water solutions and following the approach to an equilibrium cis/trans mixture as a function of time. These studies establish that the trans diol in each system is more stable than the corresponding cis diol. Thus, acid-catalyzed hydrolysis of each epoxide, which proceeds via a carbocation intermediate, yields the less stable cis diol as the major product. Transition-state effects, presumably of a hydrogen-bonding nature, selectively stabilize the transition state for attack of water on the intermediate 2-hydroxy-1-indanyl carbocation leading to the less stable cis diol in this system. Transition-state effects must also be responsible for formation of the less stable cis diol as the major product in the acid-catalyzed hydrolysis of 5-methoxy-1,2,3,4-tetrahydronaphthalene 1,2-epoxide. However, in this system steric effects at the transition state may be more important than hydrogen bonding in determining the cis/trans diol product ratio. The synthesis of 5-methoxyindene 1,2-oxide and a study of its rate of reaction as a function of pH in water and dioxane-water solutions are reported. Both an acid-catalyzed reaction leading to only diol products and a pH-independent reaction yielding 71% of 5-methoxy-2-indanone and 29% of diols are observed; the half-life of its pH-independent reaction in water is only 2.4 s.

Substituent Effect Behavior in the Antiaromatic Inden-1-yl Cation System

Studies of the rate-accelerating effects in solvolysis produced by 5-methyl and 5-methoxy substituents on the benzene ring and a 3-methyl substituent on the double bond of the inden-1-yl 3,5-dinitrobenzolate system have been carried out.In both 80percent aqueous acetone and in 2,2,2-trifluoroethanol, the rate accelerations observed in the inden-1-yl system were approximately the same as those found in model cyclopenten-3-yl and indan-1-yl systems.From these results, it is concluded that delocalization of charge into both the benzene ring and double bond of the 8?-electron inden-1-yl carbocation is taking place and is apparently undiminished by antiaromatic effects.