319924-91-9

Upstream product

• 529-35-1 5,6,7,8-Tetrahydronaphthalen-1-ol 

Downstream Products

• 1380075-79-5 ethyl N-[4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-yl]malonamate 
• 1380075-77-3 4-(4-benzyloxy-3-isopropylphenoxy)-3-bromo-5,6,7,8-tetrahydronaphthalen-1-ylamine 
• 575503-13-8 ethyl N-[7-(4-hydroxy-3-isopropylphenoxy)-6-methylindan-4-yl]malonamate 
• 575505-27-0 4-(7-amino-5-methylindan-4-yloxy)-2-isopropylphenol 
• 1380075-76-2 5-(4-benzyloxy-3-isopropylphenoxy)-6-bromo-8-nitro-1,2,3,4-tetrahydronaphthalene 

Relevant academic research and scientific papers

SULFONIMIDAMIDE COMPOUNDS AS NLRP3 MODULATORS

Described herein are compounds of Formula (I), Formula (I-A), and Formula (I-B), solvates thereof, tautomers thereof, and pharmaceutically acceptable salts of the foregoing, Further described herein are methods of inhibiting NLRP3 using said compounds, and methods of and compositions useful in treating NLRP3-dependent disorders.

Novel spla2 inhibitors

A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.