320-62-7

Usage

Uses

Used in Organic Synthesis:
3-CHLORO-4-(TRIFLUOROMETHYL)BENZOYL FLUORIDE is used as a reagent in organic synthesis for its strong electrophilic properties, which are beneficial in the synthesis of various organic compounds.
Used in Pharmaceutical Production:
In the pharmaceutical industry, 3-CHLORO-4-(TRIFLUOROMETHYL)BENZOYL FLUORIDE is utilized as an intermediate in the production of various pharmaceuticals, contributing to the development of new medications.
Used in Agrochemical Production:
3-CHLORO-4-(TRIFLUOROMETHYL)BENZOYL FLUORIDE also serves as an intermediate in the production of agrochemicals, playing a role in the creation of substances that help protect crops and enhance agricultural productivity.
Used in the Production of Fine Chemicals:
3-CHLORO-4-(TRIFLUOROMETHYL)BENZOYL FLUORIDE is employed in the synthesis of fine chemicals, which are high-purity chemicals used in various specialized applications, such as in the fragrance, flavor, and chemical research industries.
Safety Precautions:
Due to its reactive nature, 3-CHLORO-4-(TRIFLUOROMETHYL)BENZOYL FLUORIDE should be handled with care and stored according to safety regulations to prevent accidents and ensure the safety of personnel and the environment.

Upstream product

• 115754-20-6 3-chloro-4-(trifluoromethyl)benzoic acid 

Downstream Products

• 129322-80-1 1-[3-chloro-4-(trifluoromethyl)phenyl]ethanone 

Relevant academic research and scientific papers

Deoxyfluorination of Carboxylic, Sulfonic, Phosphinic Acids and Phosphine Oxides by Perfluoroalkyl Ether Carboxylic Acids Featuring CF2O Units

The deoxyfluorination of carboxylic, sulfonic, phosphinic acids and phosphine oxides is a fundamentally important approach to access acyl fluorides, sulfonyl fluorides and phosphoric fluorides, thus the development of inexpensive, stable, easy-to-handle, versatile, and efficient deoxyfluorination reagents is highly desired. Herein, we report the use of potassium salts of perfluoroalkyl ether carboxylic acids (PFECA) featuring CF2O units as deoxyfluorination reagents, which are generated mainly as by-products in the manufacture of hexafluoropropene oxide (HFPO). The synthesis of acyl fluorides, sulfonyl fluorides and phosphoric fluorides can be realized via carbonic difluoride (COF2) generated in situ from thermal degradation of the PFECA salt.

Fluorination method

In order to overcome the problems of high cost and low stability of the existing fluorination reagents for preparing acyl fluoride, sulfonyl fluoride and phosphoryl fluoride compounds, the invention provides a fluorination method, which comprises the following operation steps of: adding a fluorination reagent into a substrate, wherein the fluorination reagent comprises cations M and anions, the anions are selected from one or more of perfluoropolyether chain carboxylic acid anions as shown in the specification: CF3(OCF2)nCO2, wherein n is selected from 1-10; the substrate comprises a carboxylic acid compound, a sulfonic acid compound, a phosphoric acid compound and a phosphine oxide compound; and carrying out fluorination reaction to obtain acyl fluoride, sulfonyl fluoride and phosphoryl fluoride products. According to the fluorination method provided by the invention, the perfluoropolyether chain carboxylate is used as a fluorination reagent, so that the dehydroxylation fluorination reaction of the carboxylic acid compound, the sulfonic acid compound and the phosphoric acid compound and the fluorination reaction of the phosphine oxide compound are realized, the product yield isrelatively high, and the fluorination method has relatively good universality for different substrates.