320-84-3

Basic information

• Product Name: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE
• Synonyms: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE;4-Chloro-2-(chlorocarbonyl)benzotrifluoride, 5-Chloro-alpha,alpha,alpha-trifluoro-o-toluoyl chloride
• CAS NO: 320-84-3
• Molecular Formula: C₈H₃Cl₂F₃O
• Molecular Weight: 243.01
• Mol File: 320-84-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 214-217 °C
• Appearance: /
• Density: 1.506±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(320-84-3)
• EPA Substance Registry System: 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE(320-84-3)

Safety Data

• Hazard Codes: C
• HazardClass: CORROSIVE
• Hazardous Substances Data: 320-84-3(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is a chemical compound with the molecular formula C8H4ClF3O. It is a chlorinated benzoyl chloride with a trifluoromethyl group attached to the benzene ring. 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE is often used as a versatile building block in the synthesis of pharmaceuticals and agrochemicals. It is also employed in the manufacturing of dyes, polymers, and various organic compounds. Due to its reactivity, it is important to handle 5-CHLORO-2-(TRIFLUOROMETHYL)BENZOYL CHLORIDE with care, using appropriate safety measures and protective equipment to avoid potential hazards.

Upstream product

• 320-85-4 4-chloro-2-difluoromethyl-1-trifluoromethyl-benzene 
• 654-98-8 5-chloro-2-(trifluoromethyl)benzoic acid 
• 90381-07-0 5-chloro-2-(trifluoromethyl)benzaldehyde 

Downstream Products

• 1394017-33-4 5-chloro-N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide 
• 1394017-73-2 5-chloro-N-(3-methyl-1-(4-nitrophenyl)-1-oxobutan-2-yl)-2-(trifluoromethyl)benzamide 

Relevant articles and documents

FUSED MORPHOLINOPYRIMIDINES AND METHODS OF USE THEREOF

The present disclosure relates to Fused Morpholinopyrimidines, pharmaceutical compositions comprising an effective amount of a Fused Morpholinopyrimidine and methods for using a Fused Morpholinopyrimidine in the treatment of a neurodegenerative disease, comprising administering to a subject in need thereof an effective amount of a Fused Morpholinopyrimidine.

Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2, 1-a]isoindol-6(2H)-one, a selective, orally active agonist of the 5-HT 2C receptor

Robust pharmaceutical treatment of obesity has been limited by the undesirable side-effect profile of currently marketed therapies. This paper describes the synthesis and optimization of a new class of pyrazinoisoindolone- containing, selective 5-HT2C agonists as antiobesity agents. Key to optimization of the pyrazinoisoindolone core was the identification of the appropriate substitution pattern and functional groups which led to the discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a] isoindol-6(2H)-one (58), a 5-HT2C agonist with > 300-fold functional selectivity over 5-HT2B and > 70-fold functional selectivity over 5-HT2A. Oral dosing of 58 reduced food intake in an acute rat feeding model, which could be completely reversed by a selective 5-HT2C antagonist and caused a reduction in body weight gain in a 4-day rat model.