32001-55-1

Basic information

• Product Name: Pyridine hydrofluoride
• Synonyms: PYRIDINIUM POLY(HYDROGEN FLUORIDE);PYRIDINIUM POLY(HYDROGEN FLUORIDE) COMPLEX;PYRIDINE POLYFLUORIDE HYDROFLUORIDE;HF;HF 55% IN PYRIDINE;HF 70% IN PYRIDINE;HYDROGEN FLUORIDE PYRIDINE COMPLEX;Olahs
• CAS NO: 32001-55-1
• Molecular Formula: C₅H₆N*F
• Molecular Weight: 99.11
• EINECS: 250-889-6
• Mol File: 32001-55-1.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 50°C 1mm
• Flash Point: 50°C/1mm
• Appearance: Clear pale yellow to light brown/Liquid
• Density: 1.1 g/mL at 20 °C(lit.)
• Vapor Pressure: 22.8mmHg at 25°C
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform
• Sensitive: Moisture Sensitive
• BRN: 4750151
• CAS DataBase Reference: Pyridine hydrofluoride(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine hydrofluoride(32001-55-1)
• EPA Substance Registry System: Pyridine hydrofluoride(32001-55-1)

Safety Data

• Hazard Codes: T+,C
• Statements: 26/27/28-35-34
• Safety Statements: 26-28-36/37/39-45-27
• RIDADR: UN 1790 8/PG 1
• WGK Germany: 2
• F: 3-10
• TSCA: T
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 32001-55-1(Hazardous Substances Data)

Usage

Uses

Pyridinium Poly(hydrogenfluoride) is used in the synthesis of analogues of antimitotic natural product curacin A. It is also an effective fluorinating agent.

InChI:InChI=1/C5H5N.HI/c1-2-4-6-5-3-1;/h1-5H;1H

Upstream product

• 110-86-1 pyridine 
• 7664-39-3 hydrogen fluoride 

Relevant articles and documents

METHOD FOR PRODUCING 1,2,2,2-TETRAFLUOROETHYL DICHLOROMETHYL ETHER

PROBLEM TO BE SOLVED: To provide a method for efficiently manufacturing a 1,2,2,2-tetrafluoroethyl dichloromethyl ether. SOLUTION: By chlorinating 1,2,2,2-tetrafluoroethyl methylether in the presence of a radical initiator or under light irradiation, a mixture of 1,2,2,2-tetrafluoroethyl dichloromethyl ether and 1,2,2,2-tetrafluoroethyl trichloromethylether of higher order chlorinated substance is obtained. Then the obtained mixture is subjected to hydrogenolysis reaction using hydrogen to efficiently convert 1,2,2,2-tetrafluoroethyl trichloromethylether, which is a by-product difficult to separate from the mixture, into 1,2,2,2-tetrafluoroethyl dichloromethyl ether. Also, a 1,2,2,2-tetrafluoroethyl difluoromethyl ether (desflurane) useful as an inhalation anesthetic can be produced using the 1,2,2,2-tetrafluoroethyl dichloromethyl ether. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPO&INPIT

Compounds with chelation affinity and selectivity for first transition series elements: use in medical therapy

This invention involves synthesis and use of a class of compounds with chelation affinity and selectivity for first transition series elements. Administration of the free or conjugated compound, or physiological salts of the free or conjugated compound, results in decrease in the in vivo bioavailability of first transition series elements and/or removal from the body of first transition series elements and elements with similar chemical properties. These characteristics make such compounds useful in the management of diseases associated with a bodily excess of first transition series elements and elements with similar chemical properties. This invention demonstrates that such compounds inhibit mammalian, bacterial, and fungal cell replication and are therefore useful in the treatment of neoplasia, infection, inflammation, immune response, and in termination of pregnancy. Since these compounds are capable of descreasing the in vivo availability of tissue iron they are useful in management of free radical mediated tissue damage, and oxidation mediated tissue damage. When combined with radioisotopic or paramagnetic cations of first transition series elements, or elements with chemical properties similar to those of first transition series elements, prior to their administration, the resulting complexes are useful as diagnostic agents in nuclear medicine and magnetic resonance imaging (MRI).