3201-21-6

Basic information

• Product Name: 3-Ethoxy-5-methyl-1H-pyrazole
• Synonyms: 3-Ethoxy-5-methyl-1H-pyrazole;-Ethoxy-5-methyl-1H-pyrazole
• CAS NO: 3201-21-6
• Molecular Formula: C₆H₁₀N₂O
• Molecular Weight: 126.16
• Mol File: 3201-21-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 66-67 °C
• Boiling Point: 260.3°C at 760 mmHg
• Flash Point: 95.3°C
• Appearance: /
• Density: 1.071g/cm³
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.504
• PKA: 13.76±0.10(Predicted)
• CAS DataBase Reference: 3-Ethoxy-5-methyl-1H-pyrazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Ethoxy-5-methyl-1H-pyrazole(3201-21-6)
• EPA Substance Registry System: 3-Ethoxy-5-methyl-1H-pyrazole(3201-21-6)

Safety Data

• Hazardous Substances Data: 3201-21-6(Hazardous Substances Data)

Usage

General Description

3-Ethoxy-5-methyl-1H-pyrazole is a chemical compound with the molecular formula C7H10N2O. It is an organic compound that belongs to the pyrazole class of molecules. This chemical is used in the manufacturing of pharmaceuticals and agrochemicals, and it can also be used as an intermediate in organic synthesis. It has a variety of potential applications due to its unique structure and properties. However, it is important to handle this chemical with care, as it may have potential health and environmental hazards.

InChI:InChI=1/C6H10N2O/c1-3-9-6-4-5(2)7-8-6/h4H,3H2,1-2H3,(H,7,8)

Upstream product

• 141-97-9 ethyl acetoacetate 
• 110921-59-0 3-hydroxybut-2-enethioate de O-ethyle 

Downstream Products

• 140847-96-7 5-ethoxy-3-methyl-pyrazole-1-carboxylic acid anilide 
• 108-26-9 3-methyl-2-pyrazoline-5-one 

Relevant articles and documents

Zn[(l)proline]2 in water: A new easily accessible and recyclable catalytic system for the synthesis of pyrazoles

Zn[(l)proline]2 has been found to be an efficient catalyst for the synthesis of pyrazole derivatives in pure water at room temperature. Reaction afforded moderate to excellent yield within a lesser time. Various pyrazoles which could not be prepared by other methods can be easily prepared by this method efficiently. Catalyst exhibits recyclability up to five runs. Hence our present protocol is economical and clean comprise of green reagent, solvent and catalyst.

Alkoxypyrazoles and the process for their preparation

The present invention relates to a alkoxypyrazoles preparation process, and new alkoxypyrazole compounds.

Synthesis of 3-ethoxyisoxazole derivatives and 3-ethoxy-1H-pyrazole derivatives from β-oxo thionoesters

3-Ethoxyisoxazoles and 3-ethoxy-1H-pyrazoles were obtained in high yields from β-oxo thionoesters. The reaction of the ethyl β-oxo thionoesters with hydroxylamine hydrochloride in the presence of triethylamine at room temperature for 2 h gave the ethyl 3-oxopropiohydroximates and their hemiacetals, which were easily converted to the 3-ethoxyisoxazoles by refluxing for 3 h at pH 3-5. On the other hand, the reaction of the ethyl β-oxo thionoesters with hydrazine derivatives in the presence of triethylamine for 3-8 h at room temperature directly yielded the 3-ethoxy-1H-pyrazoles.