32018-43-2Relevant academic research and scientific papers
Synthesis, structure and reactivity of azosalophen complexes of vanadium(IV): Studies on cytotoxic properties
Pattanayak, Poulami,Pratihar, Jahar Lal,Patra, Debprasad,Mitra, Soham,Bhattacharyya, Arindam,Man Lee, Hon,Chattopadhyay, Surajit
experimental part, p. 6220 - 6230 (2010/02/16)
The free ligands, 2-{(o-hydroxyaryl)azo}-1-N-salicylidene phenylamine, H2L [where H2L = RC6H4NNC 6H4NCH-C6H4OHR = p-H for H 2L1, p-Me for H2L2 and p-Cl for H2L3], were prepared by the condensation of salicylaldehyde with 2-{(o-hydroxy aryl)azo} aniline. Reaction of H2L with VOSO4 afforded the oxovanadium complex, (L)V(O)(H 2O). The (L1)V(O)(H2O) complex displays two reversible responses at 0.7 V and -0.65 V vs. SCE in cyclic voltammetry. Catalytic activity of (L1)V(O)(H2O) toward H 2O2 induced oxidation of organic thioethers to sulfoxide and sulfones have been examined. The cytotoxicity of (L1)V(O)(H 2O) has also been examined on human lung cancer cells. The Royal Society of Chemistry 2009.
149. Notizen zur Synthese von 2-Aminophenylsulfonen
Courtin, Alfred,Tobel, Hans-Rudolf von,Auerbach, Guenther
, p. 1412 - 1419 (2007/10/02)
Syntheses of the alkyl, cycloalkyl and aryl 2-aminophenyl sulfones 10 were achieved by oxidation of the corresponding 2-nitrophenyl sulfides 7 to the 2-nitrophenyl sulfones 9 followed by ethanolic Bechamp-reduction.The sulfides 7 in turn were obtained by either reactions of 2-nitro-thiophenol (8) with the appropriate alkyl and cycloalkyl halides or of 2-chloro-nitrobenzene (5) with the relevant thiols.Condensation of 2-nitrobenzenesulfinic acid (3) with bromoacetic acid in aqueous alkaline solution led - presumably via 2-nitrophenylsulfonylacetic acid (4) - to methyl2-nitrophenyl sulfone (1), reduction of which gave 2-aminophenyl methyl sulfone (2).Treatment of 2-aminothiophenol (11) with t-butyl alcohol in aqueous sulfuric acid gave 2-aminophenyl t-butyl sulfide (12), which was acetylated to o-t-butylthio-acetanilide (13).Oxidation of the latter to o-t-butylsulfonyl-acetanilide (14) followed by hydrolysis led to 2-aminophenyl t-butyl sulfone (15).
