32018-86-3

Basic information

• Product Name: 3-Amino-1-naphthoic acid
• Synonyms: 3-Amino-1-naphthoic acid;3-Amino-naphthalene-1-carboxylic acid
• CAS NO: 32018-86-3
• Molecular Formula: C₁₁H₉NO₂
• Molecular Weight: 187.19
• Mol File: 32018-86-3.mol
• Article Data: 3

Chemical Properties

• Melting Point: 179 °C
• Boiling Point: 456.1±28.0 °C(Predicted)
• Appearance: /
• Density: 1.352±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: pK1: 2.61;pK2: 4.39 (25°C)
• CAS DataBase Reference: 3-Amino-1-naphthoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-1-naphthoic acid(32018-86-3)
• EPA Substance Registry System: 3-Amino-1-naphthoic acid(32018-86-3)

Safety Data

• Hazardous Substances Data: 32018-86-3(Hazardous Substances Data)

Usage

Uses

3-Aminonaphthalene-1-carboxylic acid is an intermediate for herbicide antidote. A useful synthesis intermediate.

Upstream product

• 4507-84-0 3-nitro-1-naphthoic acid 
• 3027-38-1 3-nitro-1,8-naphthalic anhydride 
• 1016-17-7 3-Nitronaphthalene-1-carbonitrile 
• 7499-65-2 4-bromo-2-nitronaphthalene 

Downstream Products

• 103907-14-8 4-amino-3-hydroxy-1-naphthalenecarboxylic acid 
• 632624-41-0 3-{2-[5-chloro-2-(2,3-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-1-naphthoic acid 
• 632624-30-7 3-{2-[5-chloro-2-(2,6-difluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-1-naphthoic acid 
• 632624-17-0 3-{2-[5-chloro-2-(4-bromo-2-fluorobenzyloxy)phenyl]-5-methyl-pyrrol-1-yl}-1-naphthoic acid 
• 19700-42-6 3-hydroxy-1-naphthalenecarboxylic acid 
• 16726-66-2 3-bromo-1-naphthoic acid 

Relevant articles and documents

Thrombopoietin mimetics

Non-peptide TPO mimetics are disclosed, as well as a method of treating thrombocytopenia, in a mammal, including a human, in need thereof, which comprises administering to such mammal an effective amount of a selected hydroxy-1-azo-naphthalene derivative.

Dissociation of naphthoic acids in non-aqueous media. Comparison of benzene and naphthalene skeletons

Seven monosubstituted 1-naphthoic acids were synthesized by new or modified procedures, and their dissociation constants were measured potentiometrically at 25 °C in methanol, acetonitrile, dimethylformamide, and pyridine. Dissociation constants of these along with thirteen substituted 1-naphthoic acids and twenty-five substituted 2-naphthoic acids previously studied were measured at 25 °C in ethanol and dimethyl sulfoxide. The pKHA values of 3-and 4-substituted 1-naphthoic acids were treated by simple linear regression and principal component analysis, and the results were used for comparison of model compounds and of corresponding 3-and 4-substituted benzoic acids with the aim of comparison of benzene and naphthalene skeletons. It has been found, the 3 and 4 positions of the 1-naphthyl system can roughly be compared with the meta and para positions of benzene, respectively.