320347-97-5

Basic information

• Product Name: 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester
• Synonyms: 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester;(R)-Quinucldin-3-yl hydroxybis(2-thienyl)acetate;2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester-5;GYDFTKNRHZMENP-ZDUSSCGKSA-N
• CAS NO: 320347-97-5
• Molecular Formula: C₁₇H₁₉NO₃S₂
• Molecular Weight: 349.46766
• Mol File: 320347-97-5.mol
• Article Data: 19

Chemical Properties

• Melting Point: 180℃ (isopropyl ether )
• Boiling Point: 513.3±50.0 °C(Predicted)
• Appearance: /
• Density: 1.40±0.1 g/cm3(Predicted)
• PKA: 10.33±0.29(Predicted)
• CAS DataBase Reference: 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester(320347-97-5)
• EPA Substance Registry System: 2-Thiopheneacetic acid, α-hydroxy-α-2-thienyl-, (3R)-1-azabicyclo[2.2.2]oct-3-yl ester(320347-97-5)

Safety Data

• Hazardous Substances Data: 320347-97-5(Hazardous Substances Data)

Usage

Uses

(R)-3-Quinuclidinyl di(2-thienyl)glycolate acts as a potent and long-acting muscarinic antagonist with minimal systemic exposure after inhalation. Used in the treatment of chronic obstructive pulmonary disease.

Upstream product

• 28569-88-2 Ethyl (2,2'-Dithienyl)glycolate 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 26447-85-8 hydroxy-di-thiophen-2-yl-acetic acid methyl ester 
• 4746-63-8 2-hydroxy-2,2-di(thiophen-2-yl)acetic acid 
• 1003-09-4 2-bromothiophene 
• 27998-36-3 2,2-di(2-thiophenyl)-2-hydroxyethanoic acid-3-quinine ester 
• 1619-34-7 3-quinuclidinol 
• 59653-40-6 (+)-Aceclidine 

Downstream Products

• 320345-91-3 (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(4-phenylbutyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 1185907-26-9 (3R)-1-benzyl-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-azoniabicyclo[2.2.2]octane bromide 
• 320345-88-8 (3R)-3-{[hydroxy(di-2-thienyl)acetyl]oxy}-1-(2-phenylethyl)-1-azoniabicyclo[2.2.2]octane bromide 
• 867022-63-7 aclidinium bromide 
• 1195981-90-8 (R)-3-(2-hydroxy-2,2-dithiophen-2-yl-acetoxy)-1-(5-phenylisoxazol-3-ylmethyl)-1-azoniabicyclo[2.2.2]octane chloride 
• 320345-99-1 aclidinium bromide 

Relevant articles and documents

A PROCESS FOR PREPARING ACLIDINIUM BROMIDE AND INTERMEDIATES THEREOF

Provided herein is a process for synthesis of aclidinium bromide and intermediates thereof, wherein the process for the preparation of aclidinium bromide increases the % yield of aclidinium bromide by about 70% to 90%.

Novel method for synthesis and purification of aclidinium bromide

The invention discloses a novel method for synthesis and purification of aclidinium bromide. According to the method, tetrahydrofuran is used, haloalkane is used as an initiator, and a finished product is obtained through solvent extraction and recrystall

High-purity high-yield aclidinium bromide preparation method suitable for industrial production

The invention discloses a high-purity high-yield aclidinium bromide preparation method suitable for industrial production. The preparation method comprises the following steps: 1) adding methyl 2,2-di(2-thienyl)-2-hydroxyacetate and TBDMSCl into solvent,