320370-39-6Relevant academic research and scientific papers
Structure-activity relationships within a series of C(7)-substitutedoxyiminocephalosporins containing the C(3)-methylaminopyridiniumthiomethyl substituent synthesis and biological properties of BRL 57342 and some close analogues
Adams,Brain,Branch,Guest,Harrington,Mizen,Neale,Pearson,Simpson,Smulders,Zomaya
, p. 417 - 424 (2007/10/02)
(6R,7R)-7-[2-(2-Amino-4-thiazolyl)-2-[(Z)-[(S)-carboxy(3,4 -dihydroxyphenyl)methyl]oxy-imino]acetamido]-3-(1-methylaminopyridinium-4 -thiomethyl)ceph-3-em-4-carboxylate sodium salt (BRL 57342, If) combines excellent in vitro antibacterial potency against Gram-positive and Gram-negative bacteria, including P. aeruginosa and Acinetobacter spp., with excellent stability to extended spectrum β-lactamases. This potency is reflected in in vivo efficacy studies.
