32039-89-7

Upstream product

• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 917-58-8 potassium ethoxide 
• 140-29-4 phenylacetonitrile 
• 97-62-1 Ethyl isobutyrate 
• 547-63-7 Methyl isobutyrate 

Downstream Products

• 32039-90-0 ethyl 4-methyl-3-oxo-2-phenylpentanoate 
• 1191387-29-7 1-(4-hydroxyphenyl)-2-isopropyl-1H-indole-3-carbonitrile 
• 1191389-66-8 2-isopropyl-1-(4-methoxyphenyl)-1H-indole-3-carbonitrile 
• 2893-05-2 3-methyl-1-phenylbutan-2-one 
• 132332-53-7 3-{2-[4-(4-Fluoro-benzoyl)-piperidin-1-yl]-ethyl}-6-isopropyl-5-phenyl-1H-pyrimidine-2,4-dione; hydrochloride 
• 132332-50-4 6-Isopropyl-5-phenyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one 
• 132332-51-5 6-Isopropyl-5-phenyl-1H-pyrimidine-2,4-dione 
• 634199-49-8 6-isopropyl-5-(4'-nitrophenyl)-pyrimidine-2,4-diamine 
• 634199-53-4 5-(4'-aminophenyl)-6-isopropyl-pyrimidine-2,4-diamine 
• 34062-03-8 6-isopropyl-5-phenyl-pyrimidine-2,4-diamine 

Relevant academic research and scientific papers

Metal-free photochemical aromatic perfluoroalkylation of α-cyano arylacetates

We report here an operationally simple protocol for the direct aromatic perfluoroalkylation and trifluoromethylation of α-cyano arylacetates. This metal-free approach, which occurs at ambient temperature and under visible-light irradiation, is driven by t

Synthesis of β-ketonitriles, α,β-alkynones and biscabinols from esters using tert-butoxide-assisted C(=O)-C (i.e., acyl-C) coupling under ambient conditions

We demonstrated the synthesis of β-ketonitriles, α,β- alkynones, and biscarbinols using tert-butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters under ambient conditions. tert-Butoxide-assisted C(CO)-C (i.e., acyl-C) coupling of esters with cyanomethylenes and acetylenes under transition metal-free ambient conditions gives β-ketonitriles, α,β-alkynones and/or aryl bis(phenylethynyl)carbinols in moderate-to-good yields. It is noteworthy that this is a rapid, facile, and efficient process under ambient conditions, and use of cheap and stable starting materials.

NOVEL ESTROGEN RECEPTOR LIGANDS

The invention provides a compound of formula (I) or a pharmaceutically acceptable ester, amide, carbamate, solvate or salt thereof, including a salt of such an ester, amide or carbamate, and a solvate of such an ester, amide, carbamate or salt. The invention also provides also provides the use of such compounds in the treatment or prophylaxis of a condition associated with a disease or disorder associated with estrogen receptor activity, wherein R1, R2, R3, R4, R5 and R6 are as defined in the specification.

A high-yielding preparation of β-ketonitriles

β-Ketonitriles are important precursors for a wide variety of biologically active heterocycles. A facile procedure for the high-yielding acylation of nitrite anions with unactivated esters to provide β-ketonitriles is reported. The procedure is successful with enolizable and nonenolizable esters as well as hindered nitrile anions.

An expeditious synthesis of 6-alkyl-5-(4′ -amino-phenyl)-pyrimidine-2,4-diamines

A rapid synthesis of a series of 6-alkyl substituted-5-(4′ -amino-phenyl)-pyrimidine-2,4-diamines is described. These analogs were produced in good yields on moderate scale (ca. 8 g) without chromatography. Furthermore, the methodology described herein al