32040-88-3Relevant academic research and scientific papers
Identification of Potent Ras Signaling Inhibitors by Pathway-Selective Phenotype-Based Screening
Mueller, Oliver,Gourzoulidou, Eleni,Carpintero, Mercedes,Karaguni, Ioanna-Maria,Langerak, Anette,Herrmann, Christian,Moeroey, Tarik,Klein-Hitpass, Ludger,Waldmann, Herbert
, p. 450 - 454 (2007/10/03)
Blocking the path to cancer: Application of efficient strategy for a phenotype-based screening of compound libraries to a library of sulindac-derived compounds (see scheme) yielded new inhibitors of the tumor-relevant Ras signal transduction pathway with high fidelity (as shown by microscopy). The results underline the advantage of using biologically prevalidated compound classes in chemical biology research.
