3206-17-5

Upstream product

• 16807-48-0 3‐acetyl‐2‐hydroxy‐6‐methyl‐4H‐pyran‐4‐one 
• 106-49-0 p-toluidine 
• 771-03-9 3-acetyl-4-hydroxy-6-methyl-2H-pyran-2-one 

Relevant academic research and scientific papers

Preparation method of high purity medical intermediate

The invention discloses a preparation method of a high purity medical intermediate, and belongs to the technical field of pharmaceutical and chemical industry. According to the preparation method, dehydro-acetic acid and aromatic amine are taken as the raw materials, 1,3,6-naphthalenetrisulfonic acid is taken as the catalyst, condensation reactions are carried out in an isopropanol water solution to prepare high purity 4-hydroxy-6-methyl-[1-(phenylimino)ethyl]-2H-pyran-2-one derivatives, and further purification is not needed. The production process is simple, the purity of synthesized product is high, and the yield is high.

Catecholase activity investigations using in situ copper complexes continuing Schiff base derivatives with a theoretical calculation

The study of catecholase activity of a series of Schiff base compounds using in situ copper complexes of 4-hydroxy-6-methyl-3-(1-(phenylimino)ethyl)-2H-pyran-2-one derivatives has been reported. The reaction rate depends on four parameters: The nature of the substitution in para position to the benzene ring, the nature of counter anion, the concentration of ligand and the nature of solvent. The highest rate activity is given by complex resulting from one equivalent of ligand L2 and two equivalents of copper acetate in methanol, which equal to 62.25 μmol.min-1.L-1.In other part, a theoretical study of such ligands using the semi-empirical method AM1 were also investigated. A good relationship founded between the maximal reaction rate (Vmax) and the HOMO energy (Pearson correlation: r=-0.794).

A novel and convenient synthesis of 4-hydroxy-6-methyl-3-(1-(phenylimino) ethyl)-2H-pyran-2-one derivatives under ultrasound irradiation

A facile, efficient and environment-friendly protocol for the synthesis of 4-hydroxy-6-methyl-3-(1-(phenylimino)ethyl)-2H-pyran-2-one derivatives has been developed by the convenient ultrasound-mediated condensation of amine with dehydroacetic acid. This method provides several advantages over current reaction methodologies including a simple work-up procedure, shorter reaction times and higher yields.