32061-16-8

Basic information

• Product Name: 1,3-dioxan-5-yl 4-methylbenzenesulfonate
• Synonyms: 1,3-dioxan-5-ol, 4-methylbenzenesulfonate; Toluene-4-sulfonic acid [1,3]dioxan-5-yl ester
• CAS NO: 32061-16-8
• Molecular Formula: C₁₁H₁₄O₅S
• Molecular Weight: 258.2909
• Mol File: 32061-16-8.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 403.5°C at 760 mmHg
• Flash Point: 197.9°C
• Density: 1.34g/cm³
• Vapor Pressure: 2.35E-06mmHg at 25°C
• Refractive Index: 1.557
• CAS DataBase Reference: 1,3-dioxan-5-yl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-dioxan-5-yl 4-methylbenzenesulfonate(32061-16-8)
• EPA Substance Registry System: 1,3-dioxan-5-yl 4-methylbenzenesulfonate(32061-16-8)

Safety Data

• Hazardous Substances Data: 32061-16-8(Hazardous Substances Data)

Usage

General Description

1,3-dioxan-5-yl 4-methylbenzenesulfonate is a chemical compound with the molecular formula C10H12O4S. It is a sulfonate ester derived from 1,3-dioxane and 4-methylbenzenesulfonyl chloride. 1,3-dioxan-5-yl 4-methylbenzenesulfonate is commonly used as a protecting group in organic synthesis to temporarily mask a hydroxyl group, preventing undesired side reactions. It is also utilized as a reagent in medication synthesis, especially in the development of pharmaceutical drugs. Additionally, it is employed in the production of various organic compounds and is known for its high purity and stability, making it a valuable chemical in the field of organic chemistry.

Upstream product

• 4740-78-7 glycerol formal 
• 98-59-9 p-toluenesulfonyl chloride 
• 5464-28-8 1,3-dioxolane-4-methanol 
• 50-00-0 formaldehyd 
• 56-81-5 glycerol 

Downstream Products

• 314266-05-2 docosanoic acid 3-hexadecanoyloxy-2-(toluene-4-sulfonyloxy)-propyl ester 
• 314266-04-1 docosanoic acid 3-decanoyloxy-2-(toluene-4-sulfonyloxy)-propyl ester 
• 314266-03-0 decanoic acid 3-acetoxy-2-(toluene-4-sulfonyloxy)-propyl ester 
• 124866-91-7 hexadecanoic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester 
• 309915-61-5 acetic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester 
• 314266-01-8 decanoic acid 3-hydroxy-2-(toluene-4-sulfonyloxy)-propyl ester 

Relevant articles and documents

Efficient synthesis of α-branched purine-based acyclic nucleosides: Scopes and limitations of the method

An efficient route to acylated acyclic nucleosides containing a branched hemiaminal ether moiety is reported via three-component alkylation of N-heterocycle (purine nucleobase) with acetal (cyclic or acyclic, variously branched) and anhydride (preferentially acetic anhydride). The procedure employs cheap and easily available acetals, acetic anhydride, and trimethylsilyl trifluoromethanesulfonate (TMSOTf). The multi-component reaction is carried out in acetonitrile at room temperature for 15 min and provides moderate to high yields (up to 88%) of diverse acyclonucleosides branched at the aliphatic side chain. The procedure exhibits a broad substrate scope of N-heterocycles and acetals, and, in the case of purine derivatives, also excellent regioselectivity, giving almost exclusively N-9 isomers.

Solid-liquid phase transfer catalysis III: synthesis of azido acyclic nucleosides of pyrimidine

A series of novel azido acyclic nucleosides of pyrimidine derivatives were prepared using solid-liquid phase transfer catalysis (S.L.P.T.C) and tested as anti-HIV agents in cell assay.

ASYMMETRIC SYNTHESIS OF D-erythro-SPHINGOSINE

D-erythro-Sphingosine 9 is a building block of cerebrosides and glycosphingolipids and was synthesized in 5 steps via an asymmetric aldol addition of the lithiated bislactim ether of cyclo-(L-Val-Gly) 4 to (2E)-hexadecenal (3) in an overall yield of 21percent.