32065-63-7 Usage
Description
1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is a chemical compound with the molecular formula C15H17N3O2S. It is a thiourea derivative featuring a phenyl group attached to the nitrogen atom. 1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is widely recognized for its potential biological activities and is commonly utilized in pharmaceutical research and drug development. Its unique chemical structure and properties make it a valuable asset in medicinal chemistry research.
Uses
Used in Pharmaceutical Research and Drug Development:
1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is used as a compound in pharmaceutical research and drug development for its potential biological activities. Its application is due to its potential anti-cancer, anti-inflammatory, and antimicrobial properties.
Used in Anticancer Applications:
In the field of oncology, 1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is used as a potential anti-cancer agent. It is being studied for its ability to target and combat various types of cancer due to its potential biological activities.
Used in Anti-Inflammatory Applications:
1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is also used as a potential anti-inflammatory agent. Its application is based on its potential to alleviate inflammation, a common factor in many diseases and conditions.
Used in Antimicrobial Applications:
In the field of infectious diseases, 1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is used as a potential antimicrobial agent. It is being investigated for its ability to inhibit the growth of microorganisms, making it a potential asset in the fight against bacterial and fungal infections.
Used in Antioxidant Applications:
1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is used as a potential antioxidant. Its application is due to its ability to inhibit certain enzymes, which can help protect cells from damage caused by free radicals.
Used in Enzyme Inhibition:
In the field of biochemistry, 1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is used as a potential enzyme inhibitor. Its application is based on its ability to inhibit certain enzymes, which can have therapeutic implications in various diseases.
Overall, 1-(2,5-DIMETHOXYPHENYL)-3-PHENYL-2-THIOUREA is a versatile compound with a wide range of potential applications in various industries, particularly in pharmaceuticals and healthcare. Its unique properties and potential biological activities make it a promising candidate for further research and development.
Check Digit Verification of cas no
The CAS Registry Mumber 32065-63-7 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,2,0,6 and 5 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 32065-63:
(7*3)+(6*2)+(5*0)+(4*6)+(3*5)+(2*6)+(1*3)=87
87 % 10 = 7
So 32065-63-7 is a valid CAS Registry Number.
InChI:InChI=1/C15H16N2O2S/c1-18-12-8-9-14(19-2)13(10-12)17-15(20)16-11-6-4-3-5-7-11/h3-10H,1-2H3,(H2,16,17,20)
32065-63-7Relevant articles and documents
Antileishmanial thioureas: Synthesis, biological activity and in Silico evaluations of new promising derivatives
Viana, Gil Mendes,Do Amaral, Lilian Henriques,Meireles, Paloma Wetler,Nunes, Raquel Pinto,Da Silva, Luiz Cláudio Rodrigues Pereira,De Sousa, Valeria Pereira,Sathler, Plínio Cunha,Cabral, Lucio Mendes,Soares, Deivid Costa,Saraiva, Elvira Maria,Santana, Marcos Vinicius,Castro, Helena Carla,De Sequeira Aguiar, Lúcia Cruz,Rodrigues, Carlos Rangel,Abreu, Paula Alvarez
, p. 911 - 919 (2018/10/31)
Leishmaniasis is a neglected tropical disease caused by protozoan parasites belonging to the genus Leishmania. Currently, the drugs available for treatment of this disease present high toxicity, along with development of parasite resistance. In order to overcome these problems, efforts have been made to search for new and more effective leishmanicidal drugs. The aim of this study was to synthesize and investigate the leishmanicidal effect of N,N′-disubstituted thioureas against Leishmania amazonensis, with evaluation of their in silico pharmacokinetics and toxicity profiles. Our results showed that different thioureas could be obtained in high to moderate yields using simple reaction conditions. Nine thiourea derivatives (3e, 3i, 3k, 3l, 3p, 3q, 3v, 3x and 3z) were active against parasite promastigotes (IC50 21.48–189.10μM), with low cytotoxicity on mice peritoneal macrophages (CC50>200μM), except for thiourea 3e (CC50=49.22μM). After that, the most promising thioureas (3k, 3l, 3p, 3q and 3v) showed IC50 ranging from 70 to 150μM against L. amazonensis amastigotes in infected macrophages. Except for thiourea 3p, the leishmanicidal activity of the derivatives were independent of nitric oxide (NO) production. Thioureas 3q and 3v affected promastigotes cell cycle without disturbing the mitochondrial membrane potential. Furthermore, our derivatives showed satisfactory theoretical absorption, distribution, metabolism, excretion, toxicity (ADMET) properties. These data indicate that thiourea derivatives are good candidates as leading compounds for the development of new leishmanicidal drugs.
