32066-34-5

Upstream product

• 42327-52-6 7-methoxy-chroman-4-one 
• 1159707-89-7 2-allyloxy-4-methoxy-1-(1-phenylvinyl)benzene 
• 131-57-7 Benzophenone-3 
• 139437-02-8 1-(2'-hydroxy-4'-methoxyphenyl)-1-phenylprop-2-en-1-ol 

Relevant academic research and scientific papers

A novel solid-phase synthesis of 2H-chromenes

A method for synthesizing substituted 2H-chromenes using TMSOTf-catalyzed polystyrene-supported succinimidyl selenide-induced intramolecular seleno-arylation of tethered alkenes as a key step has been developed. The catalytic process provides an efficient

Solid phase synthesis method of 2H-benzopyran compounds

The invention discloses a solid phase synthesis method of 2H-benzopyron compounds (I), and belongs to the field of organic chemistry. The method comprises the following steps: (1) taking crosslinked polystyrene resin (1%) as the carrier to prepare a selen

2H-chromenes generated by an iron(III) complex-catalyzed allylic cyclization

A straightforward method based on an iron(III) complex-catalyzed cyclization of 2-(1-hydroxyallyl)phenols is reported to access a large variety of 2H-chromenes. This method was applied to the total synthesis of a natural product, tephrowatsin B.

Synthesis and evaluation of the cytotoxicities of neoflavenes

The synthesis of neoflavene and neoflavenes with methoxy substituents at different positions are described. As starting materials, various salicylaldehydes were run through sequential reactions such as O-allylation, Grignard reaction, oxidation, Wittig reaction, and ring-closing metathesis to yield the target neoflavenes in good yield. Among the prepared neoflavenes, 7-methoxy-4′-methoxyneoflavene (6e) and 8-methoxy-4′- methoxyneoflavene (6f) exhibiting potential cell toxicities against various cells were disclosed. In particular, 6f which exhibited an IC50 value of 6.5 ± 2.0 and 5.1 ± 1.1 μM against gastric carcinoma and lung carcinoma cells in vitro was found, respectively. Meanwhile, the structure and activity relationship of our synthesized neoflavenes is further discussed briefly.

The Stereochemistry of Organometallic Compounds. XXXV. Hydroformylation of ortho-Propenylanilines and ortho-Propenylphenols: a New Route to 4,5-Dihydro-3H-1-benzazepines

Rhodium-catalyzed hydroformylation of readily available ortho-propenylanilines gives 4,5-dihydro-3H-1-benzazepines together with small amounts of substituted 3-methylquinolines (15percent).The regioselectivity of these reactions and the hydroformylation of related ortho-propenylphenols are discussed.

Hydroborations: A new convenient route for the preparation of 4-alkyl- (or 4-aryl)chroman-3-ones from 4-alkyl- (or 4-aryl)-2H-chromenes

Hydroboration followed by pyridinium chlorochromate oxidation of 4-alkyl- and 4-aryl-2H-chromenes [4-alkyl- and 4-aryl-(2H)1-benzopyrans] lead to the corresponding 4-substituted chroman-3-ones [4-substituted (2H)-1-benzopyran-3(4H)-ones] in good yields.