320725-59-5

Upstream product

• 20354-32-9 2-chloro-1,3,2-oxathiaphospholane 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 320725-63-1 (S)-2-{[(2S,3S,5R)-3-Azido-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethoxy]-mercapto-phosphorylamino}-3-phenyl-propionic acid methyl ester 
• 161006-88-8 2(S)-(3-deoxy-3-azidothymidyl(hydroxy)phosphorylamino)-3-phenylpropionic acid methyl ester 

Relevant academic research and scientific papers

Oxathiaphospholane approach to the synthesis of conjugates of amino acids methyl esters with nucleosides

Based upon 1,3,2-oxathiaphospholane chemistry, 5′-O-derivatization of nucleosides with the O-methyl esters of amino acids was performed and corresponding conjugates were obtained in satisfactory yield.

Conjugation of amino acid O-methyl esters with AZT-5'-O-phosphorothioate and phosphorodithioate

Based upon 1,3,2-oxathia(-dithia)phospholane chemistry, 5'-O-derivatisation of AZT with the O-methyl esters of L-phenylalanine and L-tryptophan was performed and the corresponding 5'-aminoacidophosphoramidothioates or phosphoramidodithioates of AZT were obtained in satisfactory yield. (C) 2000 Elsevier Science Ltd.