320742-16-3Relevant academic research and scientific papers
5-chloro substituted 1,5-dihydro-2H-pyrrol-2-ones as intermediates for the efficient synthesis of 5-alkylamino, 5-azido, 5-alkoxyamino, and 5-alkoxy derivatives
Nikitin,Andryukhova
, p. 89 - 92 (2001)
5-Hydroxy- 1,5-dihydro-2H-pyrrol-2-ones were converted to 5-chloro-1,5-dihydro-2H-pyrrol-2-ones 1a-d. These compounds are shown to be useful intermediates for the preparation of various 5-alkoxy, 5-alkylamino, 5-alkoxyamino, and 5-azido derivatives in high yields.
Synthesis of 5-alkyl- and 5-aryl-1,5-dihydro-2H-pyrrol-2-ones via coupling of 5-chloro-1,5-dihydro-2H-pyrrol-2-ones with organometallic compounds
Nikitin,Andryukhova
, p. 1285 - 1288 (2007/10/03)
5-Chloro-1,5-dihydro-2H-pyrrol-2-ones are easily alkylated at the 5-position by organomagnesium or organozinc compounds and diethyl sodiomalonate leading to corresponding 5-alkyl-1,5-dihydro-2H-pyrrol-2-ones in high yields.
