32094-53-4Relevant academic research and scientific papers
Metal-Free C-O Bond Functionalization: Catalytic Intramolecular and Intermolecular Benzylation of Arenes
Bering, Luis,Jeyakumar, Kirujan,Antonchick, Andrey P.
supporting information, p. 3911 - 3914 (2018/07/22)
A catalytic, metal-free intramolecular rearrangement of benzyl phenyl ethers using nitrosonium salt as a catalyst is described. The optimized reaction conditions enabled a catalytic and metal-free Friedel-Crafts alkylation reaction with benzylic alcohols, producing water as the stoichiometric byproduct. A comprehensive scope (>50 examples) for both approaches and application in drug synthesis were demonstrated. Mechanistic studies suggest a Lewis acid-based mechanism for the metal-free Friedel-Crafts reaction.
Friedel-Crafts Arylmethylation of Aromatics with Bis(chloromethyl)benzenes Catalysed by Zinc Chloride Supported on Silica Gel
Kodomari, Mitsuo,Taguchi, Shinkichi
, p. 240 - 241 (2007/10/03)
In the Friedel Crafts arylmethylation of aromatics with bis(chloromethyl)benzenes using strong Lewis acids (e.g. AlCl3, FeCl3), many side reactions such as transalkylation, dealkylation and polymerization are generally difficult to avoid; however, a similar reaction using silica gel-supported zinc chloride selectively gives a monoarylmethylated compound in high yield.
