32095-98-0Relevant academic research and scientific papers
Highly Chemo- And Enantioselective Hydrogenation of 2-Substituted-4-oxo-2-alkenoic Acids
Chen, Weiping,Jiang, Ru,Liu, Xian,Nie, Huifang,Wen, Jialin,Yao, Lin,Zhang, Xumu
supporting information, (2020/07/02)
The highly chemo- and enantioselective hydrogenation of (E)-2-substituted-4-oxo-2-alkenoic acids was established for the first time using the Rh/JosiPhos complex, affording a series of chiral α-substituted-γ-keto acids with excellent results (up to 99% yield and >99% ee) and high efficiency (up to 3000 TON). In addition, the importance of this methodology was further demonstrated by a concise and gram-scale synthesis of the anti-inflammatory drug (R)-flobufen.
Stereoselective synthesis and isomerization of the indole alkaloid murrayacarine
Johnson, Ann-Louise,Slaett, Johnny,Janosik, Tomasz,Bergman, Jan
, p. 2165 - 2170 (2008/01/27)
A short and efficient stereoselective synthesis of the indole alkaloid murrayacarine is described, including studies on its acid-induced isomerization.
