321166-01-2Relevant academic research and scientific papers
Inversion of the direction of stereoinduction in the coupling of chiral γ,δ-unsaturated fischer carbene complexes with o-ethynylbenzaldehyde
Ghorai, Binay K.,Menon, Suneetha,Lee Johnson, Dennis,Herndon, James W.
, p. 2121 - 2124 (2007/10/03)
(matrix presented) A variety of γ,δ-unsaturated carbene complexes that feature a stereogenic center at the β-carbon couple with 2-ethynylbenzaldehyde to afford hydrophenanthrene derivatives with a high degree of stereoinduction. The direction of stereoinduction is opposite for examples where the stereogenic center is acyclic vs examples where it is within a ring.
Synthetic studies towards (+)-Dihydroampullicin. Michael addition of N-Boc-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole to α-methylene lactones
Marcos,Redero,Bermejo
, p. 8451 - 8455 (2007/10/03)
The Michael addition of N-(tert-butoxycarbonyl)-2-(tert-butyldimethylsiloxy)-3-methyl-pyrrole (4) to several α-methylene lactones catalyzed by fluoride ions yielded the corresponding homologated products (26-30) with good yields. Application of this react
