32119-63-4

Upstream product

• 948-65-2 2-phenyl-indole 
• 106-89-8 epichlorohydrin 

Downstream Products

• 327049-13-8 1-(9-carbazolyl)-3-(2-phenyl-1-indolyl)-2-propanol 
• 1388759-66-7 4-(2-hydroxy-3-(2-phenyl-1H-indol-1-yl)propylthio)phenol 
• 1388759-76-9 1-(2-ethylphenylthio)-3-(2-phenyl-1H-indol-1-yl)propan-2-ol 
• 1388759-77-0 1-(2-phenyl-1H-indol-1-yl)-3-(1-phenyl-1H-tetrazol-5-ylthio)propan-2-ol 

Relevant academic research and scientific papers

Reaction of epoxypropylcarbazole derivatives with 2-phenylindole

The reactions of 9-(2,3-epoxypropyl)carbazole and the glycidyl ether of 1,3-di(9-carbazolyl)-2-propanol with 2-phenylindole were studied. The addition of the epoxypropylcarbazole derivatives to 2-phenylindole in 2-butanone in the presence of alkali at room temperature occurs at the nitrogen atom, while the addition proceeds at C(3) upon heating these epoxy compounds with 2-phenylindole.

Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors

A library of 1,3-disubstituted 2-propanols was synthesized and evaluated as low molecular weight probes for β-secretase inhibition. By screening a library of 121 1,3-disubstituted 2-propanol derivatives, we identified few compounds inhibiting the enzyme at low micromolar concentrations. The initial hits were optimized to yield a potent BACE-1 inhibitor exhibiting an IC 50 constant in the nanomolar range. Exploration of the pharmacological properties revealed that these small molecular inhibitors possessed a high selectivity over cathepsin D and desirable physicochemical properties beneficial to cross the blood-brain barrier.