321195-47-5Relevant academic research and scientific papers
Synthesis of 131I-labeled glucose-conjugated inhibitors of 06-methylguanine-DNA methyltransferase (MGMT) and comparison with nonconjugated inhibitors as potential tools for in vivo MGMT imaging
Mühlhausen, Ute,Schirrmacher, Ralf,Piel, Markus,Lecher, Bernd,Briegert, Manuela,Piee-Staffa, Andrea,Kaina, Bernd,R?sch, Frank
, p. 263 - 272 (2006)
O6-Substituted guanine derivatives are powerful agents used for tumor cell sensitization by inhibition of the DNA repair enzyme O 6-methylguanine-DNA methyltransferase (MGMT). To provide targeted accumulation of MGMT inhibitors in tu
COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE
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Page/Page column 8; 42, (2011/04/14)
The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA alkyl transferase (AGT). In general, the novel compounds
A convenient procedure for the synthesis of O6-benzylguanine derivatives by phase transfer catalysis
Liu, Xuan,Zheng, Qi-Huang,Hutchins, Gary D.,Fei, Xiangshu,Erickson, Leonard C.,Miller, Kathy D.,Mock, Bruce H.,Glick-Wilson, Barbara E.,Winkle, Wendy L.,Stone, K. Lee,Carlson, Kathy A.
, p. 941 - 952 (2007/10/03)
A convenient procedure by phase transfer catalysis has been developed for the synthesis of O6-BG (1) and its derivatives hydroxymethyl-BG (2a-c), halo-BG (3a-c, 4a-c, 5a-c, 6a-c), methoxy-BG (7), and methyl-BG (8). Compounds 2b, 2c, 4b, 4c, 5b, 5c, 6a, and 6c are new compounds.
