32121-42-9

Upstream product

• 37167-62-7 bromo-phenyl-acetic acid methyl ester 
• 106-45-6 para-thiocresol 
• 18793-81-2 methyl 2-phenyl-2-(2-tosylhydrazono)acetate 
• 15206-55-0 methyl 2-oxo-2-phenylacetate 
• 22979-35-7 Methyl phenyldiazoacetate 
• 1179348-58-3 methyl 2-(dimethyl(oxo)-λ⁶-sulfaneylidene)-2-phenylacetate 

Downstream Products

• 33534-76-8 Phenyl-p-tolylsulfanyl-acetic acid 2-dimethylamino-ethyl ester 
• 32121-54-3 Phenyl-p-tolylsulfanyl-acetic acid hydrazide 
• 5219-63-6 phenyl-p-tolylsulfanyl-acetic acid 
• 42330-81-4 rac-(R)-2-phenyl-2-(p-tolylthio)ethan-1-ol 

Relevant academic research and scientific papers

Blue light-promoted cyclopropenizations of N-tosylhydrazones in water

Carbene transfer reactions play an important role in the field of organic synthesis because of their ability to construct a variety of molecules. Herein, we reported on blue light-induced cyclopropenizations of N-tosylhydrazones in water, which avoids the use of expensive metal-based catalysts and toxic organic solvents. This metal-free and operationally simple methodology enable highly efficient cyclopropenizations, X-H insertion reactions, and cyclopropanation under mild reaction conditions.

Visible Light-Promoted Sulfoxonium Ylides Synthesis from Aryl Diazoacetates and Sulfoxides

A visible light-promoted reaction of donor/acceptor diazoalkanes with sulfoxides towards the synthesis of synthetically useful sulfoxonium ylides was reported. The reaction occurred under sole visible light irradiation without the need of any transition-metals or additives, affording the corresponding sulfoxonium ylides in moderate to good yields. The success of late-stage modification of natural isolates or drug candidates, scale-up reaction and transformation of sulfoxonium ylides to other useful molecules further rendered the approach valuable.

Blue Light-promoted Carbene Transfer Reactions of Tosylhydrazones

Metal-free photochemical carbene-transfer reactions of tosylhydrazones were developed under blue light irradiation at room temperature. This reaction constructs C?X (X=C, N, O, S) bonds and cyclopropanes from readily available and stable starting material

α-Thiocarbonyl synthesis via the FeII-catalyzed insertion reaction of α-diazocarbonyls into S-H bonds

Fe(OTf)2 was used to catalyze the insertion reaction of α-diazocarbonyls into S-H bonds at 40 °C. A wide range of α-thioesters were obtained in yields up to 96% within 24-48 h from their corresponding α-diazoesters. A variety of thiols were use

Synthesis of γ-Sulfur-Substituted Ketones via Rh(II)/Sc(III) a Cocatalyzed Three-Component Reaction of Diazo Compounds with Thiophenols and Enones

A facile method for the synthesis of γ-sulfur-substituted ketones is developed via a Rh(II)/Sc(III) cocatalyzed three-component reaction of diazo compounds with thiophenols and enones. With this method, different γ-sulfur-substituted ketones were obtained

Copper-Catalyzed Carbenoid Insertion Reactions of α-Diazoesters and α-Diazoketones into Si-H and S-H Bonds

An efficient copper-catalyzed carbenoid insertion reaction of α-diazo carbonyl compounds into Si-H and S-H bonds was developed. A wide range of α-silylesters and α-thioesters was obtained in high yields (up to 98%) from α-diazoesters using 5 mol% of a simple copper(I) salt as catalyst. Using 0.05 mol% of the same catalyst, α-diazoketones led to α-silylketones in low to good yields (up to 70%).

Catalyst-Free S–S Bond Insertion Reaction of a Donor/Acceptor-Free Carbene by a Radical Process: A Combined Experimental and Computational Study

Herein, a donor/acceptor-free carbene insertion reaction of an S–S bond through a radical process is presented. This catalyst-free reaction was thermally induced and provided the dithioketal products in moderate to high yields. A mechanism involving radical intermediates was proposed according to the computational study, and these intermediates were verified experimentally and intercepted for the first time by using a cross-coupling reaction.

Enantioselective Synthesis of α-Mercapto-β-amino Esters via Rh(II)/Chiral Phosphoric Acid-Cocatalyzed Three-Component Reaction of Diazo Compounds, Thiols, and Imines

An enantioselective method for the synthesis of α-mercapto-β-amino esters has been developed via a rhodium(II)/chiral phosphoric acid-cocatalyzed three-component reaction of diazo compounds, thiols, and imines. This transformation is proposed to proceed t

N-H and S-H insertions over Cu(I)-zeolites as heterogeneous catalysts

N-H and S-H insertion reactions of α-diazoesters into amines and thiols were conducted using various Cu(I)-zeolites, such as zeolite Y, Y USY, ZSM-5, and beta. All the Cu(I)-zeolites successfully catalyzed N-H insertion reactions with high product yields