3213-30-7

Basic information

• Product Name: 3-hydroxy-4-methoxyphenethylamine
• Synonyms: 3-hydroxy-4-methoxyphenethylamine;4-Methoxy-m-tyramine;4-Methoxytyramine;4-O-Methyldopamine;p-Methoxydopamine;Phenol, 5-(2-aminoethyl)-2-methoxy-
• CAS NO: 3213-30-7
• Molecular Formula: C₉H₁₃NO₂
• Molecular Weight: 167.21
• EINECS: 211-437-3
• Mol File: 3213-30-7.mol
• Article Data: 6

Chemical Properties

• Melting Point: 151-153 °C
• Boiling Point: 306.8°Cat760mmHg
• Flash Point: 139.3°C
• Appearance: /
• Density: 1.127g/cm³
• Vapor Pressure: 0.000418mmHg at 25°C
• Refractive Index: 1.558
• PKA: 9.58±0.10(Predicted)
• CAS DataBase Reference: 3-hydroxy-4-methoxyphenethylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-hydroxy-4-methoxyphenethylamine(3213-30-7)
• EPA Substance Registry System: 3-hydroxy-4-methoxyphenethylamine(3213-30-7)

Safety Data

• Hazardous Substances Data: 3213-30-7(Hazardous Substances Data)

Usage

General Description

3-Hydroxy-4-methoxyphenethylamine is a chemical compound that belongs to the class of organic compounds known as phenethylamines. Phenethylamines are compounds containing a phenethylamine moiety, which consists of a phenyl group substituted at the second position by an ethan-1-amine. This particular chemical is less common and not much information is available on it. It has the molecular formula C9H13NO2. Its molecular weight is 167.205 grams per mole. As its name indicates, it also has methoxy and hydroxy functional groups. The possible physical and chemical properties are predicted based on its structure, however, because of its obscurity, these predictions may not be accurate.

InChI:InChI=1/C9H13NO2/c1-12-9-3-2-7(4-5-10)6-8(9)11/h2-3,6,11H,4-5,10H2,1H3

Upstream product

• 39816-35-8 2-(3-hydroxy-4-methoxyphenyl)-1-nitroethene 
• 120-20-7 2-(3,4-dimethoxyphenyl)-ethylamine 
• 51-61-6 dopamine 
• 621-59-0 isovanillin 
• 63909-29-5 (E)-2-(benzyloxy)-1-methoxy-4-(2-nitrovinyl)benzene 
• 6346-05-0 3-benzyloxy-4-methoxybenzaldehyde 
• 36455-21-7 3-benzyloxy-4-methoxyphenylethylamine 

Downstream Products

• 39816-36-9 [2-(3-Hydroxy-4-methoxy-phenyl)-ethyl]-carbamic acid benzyl ester 
• 39816-38-1 N₂-(4-methoxy-3-hydroxyphenyl)ethylformamide 
• 114899-77-3 ecteinascidin 743 
• 114899-80-8 (1'R,6R,6aR,7R,13S,14R,16R)-5-(acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8-dihydroxy-7',9-dimethoxy-4,10,23-trimethyl-19-oxo-spiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinoline]-14-carbonitrile 
• 55161-43-8 N-{2-[3-(benzyloxy)-4-methoxyphenyl]ethyl}acetamide 
• 19456-85-0 5-(2-acetylamino-ethyl)-2-methoxy-phenol 
• 1173289-55-8 (S)-2-(3-benzoylphenyl)-N-(3-hydroxy-4-methoxyphenethyl)propanamide 
• 1268936-94-2 N-(3-hydroxy-4-methoxyphenethyl)-1-(4-bromo-2,6-dimethylphenoxy)propan-2-amine 
• 1268820-01-4 N-(3-hydroxy-4-methoxyphenethyl)-1-(4-bromo-2,6-dimethylphenoxy)propan-2-amine hydrochloride 
• 1268819-97-1 N-(3-hydroxy-4-methoxyphenethyl)-1-(4-cyano-2,6-dimethylphenoxy)propan-2-amine hydrochloride 
• 1273594-42-5 1-((E)-styryl)-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 1258843-28-5 1-methyl-1-(2-phenylethyl)-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 1273594-45-8 1-(p-nitrophenyl)-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 
• 4048-05-9 1-phenyl-6-hydroxy-7-methoxy-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Determination of Catechol-O-Methyltransferase Activity in Various Tissues by Liquid Chromatography

Catechol-O-methyltransferase activity was determined using liquid chromatography with amperometric detection.With dopamine as a substrate, the method allowed the individual determination of both posible product isomers in the various biological matrices investigated.The selectivity of the electrochemical detector proved advantageous in several aspects, including higher sample throughput, negligible blank values, and simplified chromatograms.The resolution of the reverse phase column permitted the incorporation of an internal standard, 3-methoxy-4-hydroxybenzylamine,to improve the precision to less than 4percent RSD for either the 3- or 4-O-methyl product isomers.The use of the product isomer preference ratios may be of clinical significance.

Organocatalytic enantioselective pictet-spengler reactions for the syntheses of 1-substituted 1,2,3,4-tetrahydroisoquinolines

A series of 1-substituted 1,2,3,4-tetrahydroisoquinolines was prepared from N-(o-nitrophenylsulfenyl)phenylethylamines through BINOL-phosphoric acid [(R)-TRIP]-catalyzed asymmetric Pictet-Spengler reactions. The sulfenamide moiety is crucial for the rate

Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.