321307-58-8Relevant academic research and scientific papers
Stereoselective synthesis of (2R,5R)- and (2S,5R)-5-hydroxylysine
Van Den Nieuwendijk, Adrianus M. C. H.,Kriek, Nicole M. A. J.,Brussee, Johannes,Van Boom, Jacques H.,Van Der Gen, Arne
, p. 3683 - 3691 (2007/10/03)
A stereoselective synthesis of (2S,5R)-5-hydroxylysine (1) and (2R,5R)-5-hydroxylysine (17), based on a concept involving Williams glycine template methodology and (R)-hydroxynitrile lyase for the introduction of chirality at the α-position and the side-chain, respectively, is described. This strategy offers an expeditious route towards orthogonally protected 5-hydroxylysines.
