321309-31-3 Usage
Uses
Used in Pharmaceutical Industry:
2,1,3-Benzothiadiazole-5-carbonyl chloride is used as a reactant for the preparation of phthalazinones, which are known as PARP inhibitors. These inhibitors are crucial in the treatment of cancer that is deficient in the homologous recombination (HR) dependent DNA double-strand break (DSB) repair pathway. By targeting and inhibiting PARP enzymes, phthalazinones can disrupt the cancer cell's DNA repair mechanism, leading to cell death and potentially offering a therapeutic advantage in cancer treatment.
Check Digit Verification of cas no
The CAS Registry Mumber 321309-31-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,3,0 and 9 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 321309-31:
(8*3)+(7*2)+(6*1)+(5*3)+(4*0)+(3*9)+(2*3)+(1*1)=93
93 % 10 = 3
So 321309-31-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H3ClN2OS/c8-7(11)4-1-2-5-6(3-4)10-12-9-5/h1-3H
321309-31-3Relevant academic research and scientific papers
Substitution Effect on 2-(Oxazolinyl)-phenols and 1,2,5-Chalcogenadiazole -Annulated Derivatives: Emission-Color-Tunable, Minimalistic Excited-State Intramolecular Proton Transfer (ESIPT)-Based Luminophores
G?bel, Dominik,Rusch, Pascal,Duvinage, Daniel,Stauch, Tim,Bigall, Nadja-C.,Nachtsheim, Boris J.
, p. 14333 - 14355 (2021/10/20)
Minimalistic 2-(oxazolinyl)-phenols substituted with different electron-donating and -withdrawing groups as well as 1,2,5-chalcogenadiazole-annulated derivatives thereof were synthesized and investigated in regard to their emission behavior in solution as well as in the solid state. Depending on the nature of the incorporated substituent and its position, emission efficiencies were increased or diminished, resulting in AIE or ACQ characteristics. Single-crystal analysis revealed J- and H-type packing motifs and a so-far undescribed isolation of ESIPT-based fluorophores in the keto form.
