321317-90-2Relevant academic research and scientific papers
Cyclobutene derivatives, their preparation and their therapeutic uses
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, (2008/06/13)
Compounds of formula (I): {wherein: R1and R2each represents a variety of organic groups; R3and R4each represents hydrogen or a variety of organic groups; A represents a group of formula (A-1): [wherein: R5represents hydrogen, hydroxy or alkyl, R6represents hydroxy, alkoxy, alkylthio or an amine residue, X and Y each represents oxygen or sulfur, and Z represents a direct single bond between the nitrogen atom shown and the benzene ring shown in formula (I), or an alkylene group], G represents a single bond, alkylene or substituted alkylene; the broken line represents a single or double bond; when the broken line represents a double bond, D represents a carbon atom; and E represents an ═N—O— group; when the broken line represents a single bond, D represents a CH group or a nitrogen atom, and E represents an oxygen atom, a sulfur atom, an —NH— group or a —CO— group}; and pharmaceutically acceptable salts, esters or other derivatives thereof have the ability to inhibit an ileal bile transporter and so may be used to treat or prevent hypercholesterolemia.
