321318-21-2

Basic information

• Product Name: Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI)
• Synonyms: Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI);3,4-difluoro-2-methylBenzenemethanol
• CAS NO: 321318-21-2
• Molecular Formula: C₈H₈F₂O
• Molecular Weight: 158.1453264
• Product Categories: HALIDE
• Mol File: 321318-21-2.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI)(321318-21-2)
• EPA Substance Registry System: Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI)(321318-21-2)

Safety Data

• Hazardous Substances Data: 321318-21-2(Hazardous Substances Data)

Usage

General Description

Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI) is a chemical compound with the molecular formula C8H9F2O. It is commonly used in the synthesis of pharmaceuticals and agrochemicals. Benzenemethanol, 3,4-difluoro-alpha-methyl- (9CI) is a colorless liquid at room temperature and has a boiling point of 135-137°C. It is classified as a hazardous material due to its flammability and potential health effects if handled improperly. The compound is also known by its IUPAC name 3,4-difluoro-alpha-methylbenzyl alcohol, and is often used as a building block in organic synthesis for the manufacture of various functional chemicals. Additionally, it is important to handle and store this compound with caution to prevent any potential hazards and exposure.

Upstream product

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Downstream Products

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Relevant articles and documents

A Practical and Stereoselective In Situ NHC-Cobalt Catalytic System for Hydrogenation of Ketones and Aldehydes

Homogeneous catalytic hydrogenation of carbonyl groups is a synthetically useful and widely applied organic transformation. Sustainable chemistry goals require replacing conventional noble transition metal catalysts for hydrogenation by earth-abundant base metals. Herein, we report how a practical in situ catalytic system generated by easily available pincer NHC precursors, CoCl2, and a base enabled efficient and high-yielding hydrogenation of a broad range of ketones and aldehydes (over 50 examples and a maximum turnover number [TON] of 2,610). This is the first example of NHC-Co-catalyzed hydrogenation of C=O bonds using flexible pincer NHC ligands consisting of a N-H substructure. Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized by fine-tuning of the steric bulk of pincer NHC ligands. Additionally, a bis(NHCs)-Co complex was successfully isolated and fully characterized, and it exhibits excellent catalytic activity that equals that of the in-situ-formed catalytic system. Catalytic hydrogenation is a powerful tool for the reduction of organic compounds in both fine and bulk chemical industries. To improve sustainability, more ecofriendly, inexpensive, and earth-abundant base metals should be employed to replace the precious metals that currently dominate the development of hydrogenation catalysts. However, the majority of the base-metal catalysts that have been reported involve expensive, complex, and often air- and moisture-sensitive phosphine ligands, impeding their widespread application. From a mixture of the stable CoCl2, imidazole salts, and a base, our newly developed catalytic system that formed easily in situ enables efficient and stereoselective hydrogenation of C=O bonds. We anticipate that this easily accessible catalytic system will create opportunities for the design of practical base-metal hydrogenation catalysts. A practical in situ catalytic system generated by a mixture of easily available pincer NHC precursors, CoCl2, and a base enabled highly efficient hydrogenation of a broad range of ketones and aldehydes (over 50 examples and up to a turnover number [TON] of 2,610). Diastereodivergent hydrogenation of substituted cyclohexanone derivatives was also realized in high selectivities. Moreover, the preparation of a well-defined bis(NHCs)-Co complex via this pincer NHC ligand consisting of a N-H substructure was successful, and it exhibits equally excellent catalytic activity for the hydrogenation of C=O bonds.

Exploring Tandem Ruthenium-Catalyzed Hydrogen Transfer and SNAr Chemistry

A hydrogen-transfer strategy for the catalytic functionalization of benzylic alcohols via electronic arene activation, accessing a diverse range of bespoke diaryl ethers and aryl amines in excellent isolated yields (38 examples, 70% average yield), is reported. Taking advantage of the hydrogen-transfer approach, the oxidation level of the functionalized products can be selected by judicious choice of simple and inexpensive additives.

A COMPOUND FOR INHIBITING HUMAN 11-β-HYDROXY STEROID DEHYDROGENASE TYPE 1, AND A PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

The present invention relates to a novel compound, or a stereoisomer, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) comprising the same. The invention provides a compound, which has excellent activity and solubility and is more efficiently formulated and delivered, and a pharmaceutical composition for human-11-beta-hydroxysteroid dehydrogenase type 1 comprising the same.