321380-69-2Relevant academic research and scientific papers
Syntheses of β-D-GalpNAc4SO3-(1→4)-L-IdopA2SO3, a disaccharide fragment of dermatan sulfate, and of its methyl α-L-glycoside derivative
Barroca, Nadine,Jacquinet, Jean-Claude
, p. 667 - 679 (2000)
The syntheses of sodium (sodium 2-acetamido-2-deoxy-4-O-sulfonato-β-D-galactopyranosyl)-(1→4)-(sodium 2-O-sulfonato-L-idopyran)uronate, a disaccharide fragment of dermatan sulfate, and of its methyl α-L-glycoside derivative are reported for the first time. The use of 4-O-acetyl-3,6-di-O-benzyl-2-deoxy-2-trichloroacetamido-1-O-trichloroaceti midoyl-α-D-galactopyranose, readily prepared from a D-gluco precursor, allowed the stereocontrolled and high yielding coupling with the low reactive 4-hydroxyl group of L-iduronic acid ester derivatives. Classical transformation of the disaccharide products into the target molecules was achieved in high yield. (C) 2000 Elsevier Science Ltd.
