321393-95-7

Upstream product

• 68579-60-2 2-(methylamino)-1-phenylethanol 
• 5703-26-4 4-Methoxyphenylacetaldehyde 
• 267884-96-8 N-methoxy-2-(4-methoxyphenyl)-N-methylethanamide 

Downstream Products

• 321393-99-1 2-{[2-(4-methoxy-phenyl)-1-methyl-ethyl]-methyl-amino}-1-phenyl-ethanol 
• 321394-68-7 2-{[1-benzyl-2-(4-methoxy-phenyl)-ethyl]-methyl-amino}-1-phenyl-ethanol 
• 321394-66-5 2-{[1-(4-methoxy-benzyl)-2-methyl-propyl]-methyl-amino}-1-phenyl-ethanol 
• 321394-64-3 2-{[1-(4-methoxy-benzyl)-propyl]-methyl-amino}-1-phenyl-ethanol 

Relevant academic research and scientific papers

Two general routes to 1,4-disubstituted-2,3,4,5-tetrahydro- 1H-3-benzazepines.

[structure] Two general routes to 1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepines are described. Both routes utilize an appropriately functionalized phenethylamino alcohol as the penultimate intermediate: the first route makes use of the reductive amination of a benzyl alkyl ketone with alpha-(aminomethyl)benzyl alcohol, while the second route utilizes the addition of a Grignard reagent to the oxazolidine derived from a substitued phenylacetaldehyde and alpha-(methylaminomethyl)benzyl alcohol. In all cases studied, the cis-1,4-disubstituted-2,3,4, 5-tetrahydro-1H-3-benzazepine was obtained as the major product.