3214-00-4Relevant academic research and scientific papers
Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors
Basu, Sujay,Prasad, Uppuleti Viplava,Barawkar, Dinesh A.,De, Siddhartha,Palle, Venkata P.,Menon, Suraj,Patel, Meena,Thorat, Sachin,Singh, Umesh P.,Sarma, Koushik Das,Waman, Yogesh,Niranjan, Sanjay,Pathade, Vishal,Gaur, Ashwani,Reddy, Satyanarayana,Ansari, Shariq
, p. 2843 - 2849 (2012/05/20)
A series of novel heterocyclic carboxylic acid based protein tyrosine phosphatase 1B (PTP1B) inhibitors with hydrophobic tail have been synthesized and characterized. Structure-activity relationship (SAR) optimization resulted in identification of several
Phosphonic acid derivatives as inhibitors of protein tyrosine phosphatase 1B (PTP-1B)
-
, (2008/06/13)
The invention encompasses the novel class of compounds represented by formula I, which are inhibitors of the PTP-1B enzyme. The invention also encompasses pharmaceutical compositions and methods of treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and conditions related to diabetes.
