32149-25-0

Upstream product

• 35504-85-9 (E) 4-(4-fluorophenyl)-4-oxo-2-butenoic acid 
• 77-78-1 dimethyl sulfate 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 74-88-4 methyl iodide 

Downstream Products

• 924200-01-1 methyl 7-(4-fluorophenyl)-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrido[2,3-d]pyrimidine-5-carboxylate 
• 39560-31-1 methyl 3-(4-fluorobenzoyl)-propionate 

Relevant academic research and scientific papers

Efficient synthesis of uracil-derived hexa- and tetrahydropyrido[2,3-d] pyrimidines

A reaction of 6-amino-1,3-dimethyluracil with 3-(hetero)aroylacrylic acids and their methyl esters leads to hexahydropyrido[2,3-d]pyrimidine-5-carboxylic acids or the corresponding methyl esters in high to excellent yields. One-pot oxidation of the acid d

CoA adducts of 4-oxo-4-phenylbut-2-enoates: Inhibitors of MenB from the M. tuberculosis menaquinone biosynthesis pathway

A high-throughput screen led to the discovery of 2-amino-4-oxo-4- phenylbutanoate inhibitors of the 1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) from the menaquinone biosynthesis pathway in Mycobacterium tuberculosis. However, these compounds are unstabl