32153-06-3

Upstream product

• 151-50-8 potassium cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 5763-61-1 3,4-dimethoxybenzylamine 

Downstream Products

• 131796-90-2 3-(3,4-Dimethoxyphenyl)-4-ethoxycarbonylmethyl-6,7-dimethoxyisoquinoline 
• 131769-71-6 4-Ethoxycarbonylmethyl-6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-1,2,3,4-tetrahydroisoquinolin-4-ol 
• 32153-11-0 6,7-Dimethoxy-3-(3,4-dimethoxyphenyl)-1,2-dihydroisoquinolin-4(3H)-one 

Relevant academic research and scientific papers

A Very Short Route to Fully Aromatic 2,3,8,9- and 2,3,8,9,12-Oxygenated Benzophenanthridines

Cyclisation of suitably substituted 2-benzylamino-2-phenylacetonitriles proceeds by rearrangement in sulphuric acid or anhydrous hydrogen fluoride, to give 3-aryl-1,2-dihydroisoquinolinones possessing all but two carbons of the benzophenanthridine ring system.These two carbon atoms are introduced in high yield by means of a modified Reformatski reaction and the resulting ester is cyclised in sulphuric acid, with concomitant dehydration and oxidation, to give the fully aromatic four-ring system in only four steps.