321533-70-4 Usage
Chemical Class
Pyrazole carboxaldehydes
Biological Activities
Diverse
Functional Groups
Chlorophenylthio group (-SC6H4Cl)
Methyl group (-CH3)
Trifluoromethyl group (-CF3)
Carboxaldehyde functional group (-CHO)
Chemical Structure
Pyrazole ring with substituents attached
Applications
Research and industrial applications
Drug discovery and development
Intermediate in synthesis of pharmaceuticals and agrochemicals
Check Digit Verification of cas no
The CAS Registry Mumber 321533-70-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,5,3 and 3 respectively; the second part has 2 digits, 7 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 321533-70:
(8*3)+(7*2)+(6*1)+(5*5)+(4*3)+(3*3)+(2*7)+(1*0)=104
104 % 10 = 4
So 321533-70-4 is a valid CAS Registry Number.
321533-70-4Relevant articles and documents
5-((1H-Pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5
Gilbert, Adam M.,Bursavich, Matthew G.,Lombardi, Sabrina,Georgiadis, Katy E.,Reifenberg, Erica,Flannery, Carl R.,Morris, Elisabeth A.
, p. 1189 - 1192 (2007/10/03)
A series of 5-((1H-pyrazol-4-yl)methylene)-2-thioxothiazolidin-4-one inhibitors of ADAMTS-5 (aggrecanase-2) is described. These compounds show μM functional inhibition of ADAMTS-5, and represent a new class of agents with the potential of inhibiting degradation of aggrecan, a major component of cartilage which is lost in osteoporosis. Compound 12 is noteworthy in that it has an ADAMTS-5 IC50: 1.1 μM and shows >40-fold functional selectivity over ADAMTS-4 (aggrecanase-1).
