321658-35-9Relevant academic research and scientific papers
A synthetic azinomycin analogue with demonstrated DNA cross-linking activity: Insights into the mechanism of action of this class of antitumor agent
Hartley, John A.,Hazrati, Ali,Kelland, Lloyd R.,Khanim, Ruzwana,Shipman, Michael,Suzenet, Franck,Walker, Louise F.
, p. 3467 - 3470 (2007/10/03)
An efficient synthesis of simplified azinomycin A and B analogues 1 and 2 (see picture) is described, and it is demonstrated that only 1, bearing both the epoxide and aziridine, induces interstrand cross-links in double-stranded DNA. Remarkably, a compoun
