321673-10-3Relevant academic research and scientific papers
Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: Ligand presentation using molecular rods
Ordanini, Stefania,Varga, Norbert,Porkolab, Vanessa,Thépaut, Michel,Belvisi, Laura,Bertaglia, Andrea,Palmioli, Alessandro,Berzi, Angela,Trabattoni, Daria,Clerici, Mario,Fieschi, Franck,Bernardi, Anna
, p. 3816 - 3819 (2015)
DC-SIGN antagonists were designed combining one selective monovalent glycomimetic ligand with trivalent dendrons separated by a rigid core of controlled length. The design combines multiple multivalency effects to achieve inhibitors of HIV infection, which are active in nanomolar concentration.
Structural control in thin layers of poly(p-phenyleneethynylene)s: Photophysical studies of Langmuir and Langmuir-Blodgett films
Kim, Jinsang,Levitsky, Igor A.,McQuade, D. Tyler,Swager, Timothy M.
, p. 7710 - 7718 (2002)
We present the relationship between the spatial arrangement and the photophysical properties of fluorescent polymers in thin films with controlled structures. Eight surfactant poly(p-phenyleneethynylene)s were designed and studied. These detailed studies
Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors
Pertici, Francesca,Varga, Norbert,Van Duijn, Arnoud,Rey-Carrizo, Matias,Bernardi, Anna,Pieters, Roland J.
supporting information, p. 215 - 222 (2013/03/14)
The synthesis of phenylene-ethynylene rods and their use as rigid spacers is described. Alternation of a Sonogashira reaction and silyl group cleavage was used to obtain rigid spacers with even and odd numbers of phenylene units. Preliminary applications of these rods in divalent systems are shown. Inhibition studies with Pseudomonas Aeruginosa lectin LecA showed that the rigid spacer proved greatly beneficial for the inhibitory potency.
