32179-89-8Relevant articles and documents
A Fit-for-Purpose Synthesis of (R)-2-Methylazepane
Guizzetti, Sylvain,Michaut, Antoine,Federspiel, Guillaume,Eymard, Julien,Caron, Isabelle,Quatrevaux, Sabrina,Daras, Etienne,Jolly, Sandrine,Guillemont, Jér?me,Lan?ois, David
supporting information, p. 729 - 733 (2020/01/31)
The preparation of new RSV inhibitors required an efficient synthesis of (R)-2-methylazepane ((R)-1) amenable to large-scale production to support preclinical studies. After consideration of different options, an efficient five-step synthesis relying on t
O-acetyl oximes as transformable directing groups for Pd-catalyzed C-H bond functionalization
Neufeldt, Sharon R.,Sanford, Melanie S.
supporting information; experimental part, p. 532 - 535 (2010/05/02)
[Chemical equation presented] O-Acetyl oxlmes serve as effective directing groups for Pd-catalyzed sp2 and sp3 C-H functionalization reactions. The C-H functionalization products can be subsequently transformed Into ortho- or β-functionalized ketones, alcohols, amines, and heterocycles.