321865-09-2Relevant academic research and scientific papers
N-azolylmethyl ketones as building blocks in heterocyclic synthesis: Synthesis of new polyfunctionally substituted azolylarylazophenols, azolylpyridones and azolylthiophenes
Al-Saleh, Balkis,Abdelkhalik, Mervat Mohammed,El-Apasery, Morsy Ahmed,Elnagdi, Mohammed Hilmy
, p. 171 - 175 (2003)
The title compounds 1a-b and 2 reacted with 2-arylhydrazonopropanals 3a-c to yield polyfunctionally substituted azolylarylazophenols 5 and 8. The reaction of 1b and 2 with phenylisothiocyanate in the presence of α-haloketones afforded the azolylthiophenes 12a,b and 13a,b. The reaction of 20 with α-haloketone afforded 5-benzotriazol-1 -yl-6-methyl-2-(2-oxopropylsulfanyl)nicotinonitrile 21 that was utilized as building blocks for the synthesis of condensed pyridines. Compound 21 was condensed with dimethylformamide dimethylacetal to yield thieno[2,3-b]pyridin-3-yl- N,N-dimethylformamidine derivative 22. This was further cyclized with sodium hydride to 1H-thieno[2,3-b; 4,5- b]dipyridin-4-one derivative 23.
Studies with 1-functionally substituted alkylbenzotriazoles: An efficient route for the synthesis of 1-azolylbenzotriazoles, benzotriazolylazines and benzotriazolylazoloazines
Al-Omran
, p. 1219 - 1223 (2007/10/03)
A new approach to the synthesis of pyrazole, isoxazole, pyridine and pyrazolo[1,5-a]pyrimidine derivatives is reported. The structure of the newly synthesized compounds was elucidated by elemental analyses, ir and 1H nmr spectra, and in some cases by 13C nmr investigation.
