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321907-05-5

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321907-05-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 321907-05-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,2,1,9,0 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 321907-05:
(8*3)+(7*2)+(6*1)+(5*9)+(4*0)+(3*7)+(2*0)+(1*5)=115
115 % 10 = 5
So 321907-05-5 is a valid CAS Registry Number.

321907-05-5Relevant articles and documents

Fluorosulfonyl-substituted xanthines as selective irreversible antagonists for the A1-adenosine receptor

Beauglehole,Baker,Scammells

, p. 4973 - 4980 (2000)

FSCPX (1) has been reported to be a potent, selective, and irreversible antagonist for the A1-adenosine receptor (AR). To obtain an irreversible A1AR antagonist with potentially better stability and to further elucidate the effects o

Development of Covalent, Clickable Probes for Adenosine A1and A3Receptors

Trinh, Phuc N. H.,Chong, Daniel J. W.,Leach, Katie,Hill, Stephen J.,Tyndall, Joel D. A.,May, Lauren T.,Vernall, Andrea J.,Gregory, Karen J.

supporting information, p. 8161 - 8178 (2021/06/30)

Adenosine receptors are attractive therapeutic targets for multiple conditions, including ischemia-reperfusion injury and neuropathic pain. Adenosine receptor drug discovery efforts would be facilitated by the development of appropriate tools to assist in target validation and direct receptor visualization in different native environments. We report the development of the first bifunctional (chemoreactive and clickable) ligands for the adenosine A1receptor (A1R) and adenosine A3receptor (A3R) based on an orthosteric antagonist xanthine-based scaffold and on an existing structure-activity relationship. Bifunctional ligands were functional antagonists with nanomolar affinity and irreversible binding at the A1R and A3R. In-depth pharmacological profiling of these bifunctional ligands showed moderate selectivity over A2Aand A2Badenosine receptors. Once bound to the receptor, ligands were successfully “clicked” with a cyanine-5 fluorophore containing the complementary “click” partner, enabling receptor detection. These bifunctional ligands are expected to aid in the understanding of A1R and A3R localization and trafficking in native cells and living systems.

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