321915-62-2Relevant academic research and scientific papers
COMBINATION OF A BIS-THIAZOLIUM SALT OR A PRECURSOR THEREOF AND ARTEMISININ OR A DERIVATIVE THEREOF FOR TREATING ACUTE MALARIA
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, (2011/07/08)
The present invention relates to a combination of antimalarial active ingredients, namely a bisthiazolium salt or a precursor thereof and artemisinin or derivatives thereof. The invention also relates to a pharmaceutical composition comprising such a combination and use thereof in the treatment and/or prevention of malaria.
Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials
Caldarelli, Sergio A.,Boisbrun, Michel,Alarcon, Karine,Hamze, Abdallah,Ouattara, Mahama,Salom-Roig, Xavier,Maynadier, Marjorie,Wein, Sharon,Peyrottes, Suzanne,Pellet, Alain,Calas, Michle,Vial, Henri
supporting information; experimental part, p. 3953 - 3956 (2010/09/03)
We report here the synthesis and biological evaluation of a series of 37 compounds as precursors of potent antimalarial bis-thiazolium salts (T3 and T4). These prodrugs were either thioester, thiocarbonate or thiocarbamate type and were synthesized in one
