321971-88-4

Upstream product

• 4785-67-5 1,1-dioxo-tetrahydro-1λ⁶-thiophene-3-carboxylic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 17236-20-3 3-(hydroxymethyl)tetrahydrothiophene 1,1-dioxide 

Downstream Products

• 1453861-63-6 2-(3-(4-((2’-chloro-4’-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-62-5 ethyl 2-(3-(4-((2’-chloro-4’-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453861-48-7 2-(3-(4-((4’-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetic acid 
• 1453861-47-6 ethyl 2-(3-(4-((4’-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methoxy)phenyl)oxetan-3-yl)acetate 
• 1453862-17-3 ethyl 2-(3-(4-(((4'-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)oxetan-3-yl)acetate 
• 1453862-18-4 2-(3-(4-(((4'-((1,1-dioxidotetrahydrothiophen-3-yl)methoxy)-2',6'-dimethyl-[1,1'-biphenyl]-3-yl)methyl)amino)phenyl)oxetan-3-yl)acetic acid 
• 1351990-45-8 4-{4-[4-(1,1-dioxo-tetrahydro-1λ6-thiophen-3-ylmethoxy)-indol-1-yl]-pyrimidin-2-ylamino}-cyclohexanecarboxylic acid ethyl ester 

Relevant academic research and scientific papers

PHENYL ALKANOIC ACID DERIVATIVES AS GPR AGONISTS

The present invention relates to phenyl alkanoic acid derivatives (the compounds of Formula (I)); and their isotopic forms, stereoisomeric and tautomeric forms and mixtures thereof in all ratios, or pharmaceutically acceptable salts, pharmaceutically acceptable solvates, prodrugs, polymorphs, N-oxides, S-oxides or carboxylic acid isosteres thereof. The invention also relates to processes for the preparation of compounds of Formula (I) and pharmaceutical compositions comprising one or more of the compounds of Formula (I). The said compounds and the pharmaceutical composition function as GPR (G-protein coupled receptor) agonists, particularly as GPR40 agonists, and are useful in the treatment of diseases or conditions mediated by GPR40. The present invention further relates to a method of treatment of diseases or conditions mediated by GPR40comprising administering to a subject in need thereof a therapeutically effective amount of the compounds of Formula (I).

Inhibitors of JNK

Compounds of formula I or pharmaceutically acceptable salts thereof, wherein: wherein m, n, p, q, X Y, Z, A, R1, R2, R3, R4, R5 and Y6 are as defined herein. The compounds and compositions

Inhibitors of JNK

Compounds of formula I or pharmaceutically acceptable salts thereof, wherein R5 is a group of formula (a) or (b): and wherein m, n, p, q, X, Y, R1, R2, R3, R4, R5, R6, R7/s

PHENOTHIAZIN DERIVATES, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF AS PHARMACEUTICALS

The invention relates to compounds of the formula 1, wherein R1, R2, R3, R4, R5, R6, R7, A and B are as defined herein, the pharmaceutical compositions and the uses as pharmaceuticals.