32199-97-6

Basic information

• Product Name: Propargyl-PEG14-alcohol
• Synonyms: Propargyl-PEG14-alcohol
• CAS NO: 32199-97-6
• Molecular Formula: C29H56O14
• Molecular Weight: 0
• Mol File: 32199-97-6.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 177.2℃ at 101.3kPa
• Appearance: /
• Density: 1.032 at 20℃
• Vapor Pressure: 1.98hPa at 20℃
• Solubility: Soluble in Water, DMSO, DMF, DCM
• CAS DataBase Reference: Propargyl-PEG14-alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: Propargyl-PEG14-alcohol(32199-97-6)
• EPA Substance Registry System: Propargyl-PEG14-alcohol(32199-97-6)

Safety Data

• Hazardous Substances Data: 32199-97-6(Hazardous Substances Data)

Usage

Description

Propargyl-PEG14-alcohol is a propargyl linker that enables Click Chemistry with azide compounds to yield stable triazole linkage. The PEG spacer enhances the hydrophilicity of the molecule in aqueous media.

Uses

Used in Pharmaceutical Industry:
Propargyl-PEG14-alcohol is used as a pharmaceutical intermediate for the synthesis of drug conjugates and prodrugs. The propargyl linker allows for efficient and selective conjugation of bioactive molecules through Click Chemistry, while the PEG spacer improves the solubility and stability of the resulting conjugates in aqueous media.
Used in Bioconjugation:
Propargyl-PEG14-alcohol is used as a bioconjugation agent for the attachment of biomolecules, such as peptides, proteins, and nucleic acids, to various surfaces and nanoparticles. The propargyl group enables efficient and site-specific conjugation through Click Chemistry, while the PEG spacer provides steric stabilization and reduces non-specific interactions.
Used in Drug Delivery Systems:
Propargyl-PEG14-alcohol is used as a component in the design of drug delivery systems, such as nanoparticles, liposomes, and hydrogels. The propargyl linker allows for the covalent attachment of therapeutic agents, while the PEG spacer enhances the biocompatibility, circulation time, and stability of the delivery system in biological environments.