32213-74-4Relevant academic research and scientific papers
Regio-and stereoselective 1,3-dipolar cycloaddition of C-aryl-N- phenylnitrones over (E)-arylidene-(2H)-indan-1-ones: Synthesis of highly substituted novel spiro-isoxazolidines
Wannassi, Nadia,Rammah, Mohamed Mehdi,Boudriga, Sarra,El Baker Rammah, Mohamed,Monnier-Jobe, Karin,Ciamala, Kabula,Knorr, Michael,Enescu, Mironel,Rousselin, Yoann,Kubicki, Marek M.
, p. 2749 - 2762 (2010)
Synthesis of a series of novel spiro-isoxazolidines has been accomplished in good yields by regio-and diastereoselective 1,3-dipolar cycloaddition of (E)-2-arylidene-(2H)-indan-1-ones 1a-d to C-aryl-N-phenylnitrones 2e-h. The structure of the spiro-adduct
Trifluoromethyl Vinyl Sulfide: A Building Block for the Synthesis of CF3S-Containing Isoxazolidines
Riesco-Domínguez, Alejandra,Van De Wiel, Jeroen,Hamlin, Trevor A.,Van Beek, Bas,Lindell, Stephen D.,Blanco-Ania, Daniel,Bickelhaupt, F. Matthias,Rutjes, Floris P. J. T.
, p. 1779 - 1789 (2018/02/23)
Trifluoromethyl vinyl sulfide, a potential building block for pharmaceutically and agrochemically relevant products, is prepared and used for the first time in high-pressure-mediated 1,3-dipolar cycloaddition reactions with nitrones to synthesize (trifluoromethyl)sulfanyl isoxazolidines.
Coupling of N -Nosylhydrazones with Nitrosoarenes: Transition-Metal-Free Approach to (Z)- N -Arylnitrones
Liu, Tingting,Liu, Zhaohong,Liu, Zhenhua,Hu, Donghua,Wang, Yeming
, p. 1728 - 1736 (2018/02/14)
An efficient and transition-metal-free protocol for the synthesis of (Z)- N -arylnitrones from the direct coupling of N -nosylhydrazones with nitrosoarenes under mild conditions is described. The protocol is compatible with a wide range of functional groups placed on both the reagents and provided the corresponding nitrones in good to excellent yields by simple recrystallization process. The use of these 1,3-dipoles for the synthesis of substituted indoles is elaborated for 2,3-diphenyl-1 H -indole.
Synthesis of C, N-diaryl nitrones from the reduction of nitroarene with aromatic aldehydes promoted by metallic samarium
Jia, Xueshun,Li, Dafeng,Huang, Qing,Zhu, Li,Li, Jian
, p. 308 - 309 (2008/02/08)
A mild and facile reduction of nitroarene with aromatic aldehydes promoted by metallic samarium to C, N-diaryl nitrones in moderate yields has been developed.
Microwave mediated synthesis of spiro-(indoline-isoxazolidines): Mechanistic study and biological activity evaluation
Raunak,Kumar, Vineet,Mukherjee, Shubhasish,Poonam,Prasad, Ashok K.,Olsen, Carl E.,Sch?ffer, Susan J.C.,Sharma, Sunil K.,Watterson, Arthur C.,Errington, William,Parmar, Virinder S.
, p. 5687 - 5697 (2007/10/03)
Regioisomeric spiro-(indoline-isoxazolidines) have been synthesized in moderate yields by the cycloaddition reaction between ethyl (3-indolylidene) acetate and various substituted α,N-diphenylnitrones, using environmentally benign microwave technology. A
1,3-Dipolar cycloaddition reactions of nitrones to prop-1-ene-1,3-sultone
Tian, Li,Xu, Guo-Yan,Ye, Yong,Liu, Lun-Zu
, p. 1329 - 1334 (2007/10/03)
The reaction of prop-1-ene-1,3-sultone (1) with a variety of nitrones 2 afforded novel [3+2] cycloaddition products 3, 4, and 5 in good yield. Excellent regio- and stereoselectivity were achieved in the cycloaddition reaction with phenylnitrones.
Regio- and stereoselectivity of captodative olefins in 1,3-dipolar cycloadditions. A DFT/HSAB theory rationale for the observed regiochemistry of nitrones
Herrera,Nagarajan,Morales,Mendez,Jimenez-Vazquez,Zepeda,Tamariz,Tamariz
, p. 1252 - 1263 (2007/10/03)
Captodative olefins 1-acetylvinyl carboxylates proved to be highly regioselective dipolarophiles in 1,3-dipolar cycloadditon to propionitrile oxide, arylphenylnitrile imines, diazoalkanes, and nitrones to yield the corresponding 5-substituted heterocycles
