32215-84-2Relevant articles and documents
Regioselective carbonylation of trans-disubstituted epoxides to β-lactones: A viable entry into syn-aldol-type products
Mulzer, Michael,Whiting, Bryan T.,Coates, Geoffrey W.
supporting information, p. 10930 - 10933 (2013/08/23)
Two new catalysts are reported for the regioselective carbonylation of trans-disubstituted epoxides to cis-β-lactones. The two catalysts display high and opposing selectivities, which generally are difficult to achieve for this class of epoxides. The resulting β-lactones are well-defined precursors for a wide variety of aldol-type compounds. Altogether, carbonylation of disubstituted epoxides is established as a viable and economical entry into syn- and anti-aldol products.
